Water-soluble esterified cellulose ethers

Patent metadata

Field	Value
Publication number	US-2018072818-A1
Application number	US-201615550094-A
Country	US
Kind code	A1
Filing date	Mar 8, 2016
Priority date	Mar 16, 2015
Publication date	Mar 15, 2018
Grant date	—

Abstract

1. An esterified cellulose ether which i) comprises groups of the formula —C(O)—R—COOH or a combination of aliphatic monovalent acyl groups and groups of the formula —C(O)—R—COOH, wherein R is a divalent hydrocarbon group, ii) has a weight average molecular weight M w of up to 70,000 Dalton, iii) has a degree of neutralization of the groups —C(O)—R—COOH of not more than 0.4, and iv) has a solubility in water of at least 2.0 weight percent at 2° C., is useful for preparing enteric capsules.

First claim

1 . An esterified cellulose ether
i) comprising groups of the formula —C(O)—CH 2 —CH 2 —COOH or a combination of acetyl groups and groups of the formula —C(O)—CH 2 —CH 2 —COOH, ii) having a weight average molecular weight M w of up to 70,000 Dalton, iii) having a degree of neutralization of the groups —C(O)—CH 2 —CH 2 —COOH of not more than 0.4, and iv) having a solubility in water of at least 2.0 weight percent at 2° C.

2 . The esterified cellulose ether of claim 1 having a Polydispersity Man, of not more than 2.0.

3 . The esterified cellulose ether of claim 1 having a viscosity of up to 13 mPa·s, measured as a 10 wt.-% solution of the esterified cellulose ether in acetone at 20° C.

4 . The esterified cellulose ether of claim 1 wherein at least 85 wt. % of the esterified cellulose ether is soluble in a mixture of 2.5 weight parts of the esterified cellulose ether and 97.5 weight parts of water at 2° C.

5 . The esterified cellulose ether of claim 1 wherein at least 85 wt. % of the esterified cellulose ether is soluble in a mixture of 10 weight parts of the esterified cellulose ether and 90 weight parts of water at 2° C.

6 . The esterified cellulose ether of claim 1 being hydroxypropyl methyl cellulose acetate succinate.

7 . A liquid composition comprising at least one esterified cellulose ether of claim 1 dissolved in an aqueous diluent.

8 . A liquid composition comprising at least one esterified cellulose ether of claim 1 and an organic diluent.

9 . The liquid composition of claim 7 comprising at least 5 weight percent of the esterified cellulose ether, based on the total weight of the liquid composition.

10 .- 11 . (canceled)

12 . A coated dosage form wherein the coating comprises at least one esterified cellulose ether of claim 1 .

13 . A polymeric capsule shell comprising at least one esterified cellulose ether of claim 1 .

14 . A capsule comprising a capsule shell of claim 13 and further comprising a drug or a nutritional or food supplement or a combination thereof.

15 . A solid dispersion of at least one active ingredient in at least one esterified cellulose ether of claim 1 .

16 . The liquid composition of claim 8 comprising at least 5 weight percent of the esterified cellulose ether, based on the total weight of the liquid composition.

Assignees

• Dow Global Technologies Llc

Inventors

• Petermann Oliver
• Knarr Matthias

Classifications

• A61K9/4816

  Wall or shell material · CPC title

• A61K9/4866

  Organic macromolecular compounds · CPC title

• A61K9/4833

  Encapsulating processes; Filling of capsules (mechanical aspects A61J3/07) · CPC title

• C08B13/00 Primary

  Preparation of cellulose ether-esters · CPC title

• A23P20/105

  Coating with compositions containing vegetable or microbial fermentation gums, e.g. cellulose or derivatives; Coating with edible polymers, e.g. polyvinyalcohol · CPC title