Liposome composition using sugar alcohol with modified surface area and/or porosity as carrier and method for preparing same

Patent metadata

Field	Value
Publication number	US-2018071392-A1
Application number	US-201515546416-A
Country	US
Kind code	A1
Filing date	Jul 1, 2015
Priority date	Jan 28, 2015
Publication date	Mar 15, 2018
Grant date	—

Abstract

The present disclosure relates to a method for preparing a novel sugar alcohol with a modified, that is, increased or decreased surface area and/or porosity while having flowability as a solid phase, and also to a sugar alcohol prepared by the preparing method or a pharmaceutical composition, a cosmetic composition, a food composition and a feed composition, comprising the sugar alcohol as a carrier. According to the present disclosure, the method for preparing a sugar alcohol comprises: (A) reacting the sugar alcohol in a solid state with a solvent (S), wherein the solid state sugar alcohol is not dissolved by the solvent (S) and is reacted with the solvent (S) as a solid dispersion; and (B) removing the solvent (S) therefrom. The sugar alcohol prepared by the preparing method of the present disclosure has a modified, that is, increased or decreased surface area and/or porosity in comparison with a conventional sugar alcohol. When the sugar alcohol prepared by the preparing method of the present disclosure is used as a carrier, a coating object, etc., or as a component of compositions for drugs, food, cosmetics, feed, etc., a ratio of an active ingredient to the carrier can be modified, so that the sugar alcohol can be used in preparing of formulations or compositions.

First claim

1 . A method for preparing a sugar alcohol with a modified surface area and/or porosity while having flowability as a solid phase, the method, comprising:
(A) reacting the sugar alcohol in a solid state with a solvent (S), in which the sugar alcohol is not dissolved by the solvent (S) and is reacted with the solvent (S) as a solid dispersion; and (B) removing the solvent (S) therefrom, wherein the solvent (S) is an organic solvent (S-1) or a water-mixed organic solvent (S-2), wherein the organic solvent (S-1), which has to be used by 30 mL or more to dissolve 1 g of the sugar alcohol, is a single or mixed solvent, and the water-mixed organic solvent (S-2) is a mixed solvent of water and the organic solvent (S-1), in which a ratio of water is less than 50% (v/v) of the total solvent.

2 . The method of claim 1 , wherein the method for preparing a sugar alcohol with an increased surface area and/or porosity while having flowability as a solid phase,
wherein the organic solvent (S-1) is a polar organic solvent.

3 . The method of claim 2 , wherein a polarity of the organic solvent (S-1) is 30 to 90% (v/v) of water.

4 . The method of claim 2 , wherein the organic solvent (S-1) is C1-C5 alcohols, C6-C10 aromatic alcohols, C1-C5 amino alcohols, C1-C4 carboxylic acids, C1-C4 amides or a mixture thereof.

5 . The method of claim 1 , wherein the method for preparing a sugar alcohol with a decreased surface area and/or porosity while having flowability as a solid phase
wherein the organic solvent (S-1) is a non-polar organic solvent.

6 - 8 . (canceled)

9 . The method of claim 5 ,
wherein the organic solvent (S-1) is chloroform or a mixed solvent including the same.

10 . The method of claim 1 , wherein the sugar alcohol is mannitol, sorbitol, xylitol, erythritol, arabitol, maltitol, inositol, lactitol, isomalt, fucitol, or a mixture thereof.

11 - 12 . (canceled)

13 . The method of claim 1 , wherein a reaction time of the step (A) is one or more minutes.

14 . The method of claim 1 , wherein a reaction time of the step (A) is one hour or less.

15 . The method of claim 1 , wherein a reaction of the step (A) is to mix or stir the sugar alcohol and the solvent (S).

16 . The method of claim 1 , wherein the step (B) is performed with drying at room temperature, hot air drying, freeze-drying or drying under the reduced pressure.

17 . (canceled)

18 . A pharmaceutical composition prepared by the method of claim 1 , wherein the pharmaceutical composition comprises a sugar alcohol with an increased surface area/or porosity while having flowability as a solid phase.

19 . (canceled)

20 . A cosmetic composition prepared by the method of claim 1 , wherein the cosmetic composition comprises a sugar alcohol with a modified surface area/or porosity while having flowability as a solid phase.

21 - 32 . (canceled)

Assignees

• Univ Soonchunhyang Ind Acad Coop Found

Inventors

• Song Keon-Hyoung

Classifications

• A61K47/36

  Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin · CPC title

• A61K9/127

  Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant · CPC title

• A61K47/30

  Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates · CPC title

• A61K8/60

  Sugars; Derivatives thereof · CPC title

• A61K9/1271

  Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers (liposomes as conjugates {A61K47/6911}) · CPC title