Zero voltage mass spectrometry probes and systems
US-9786478-B2 · Oct 10, 2017 · US
Zero voltage mass spectrometry probes and systems
US2018061620A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2018061620-A1 |
| Application number | US-201715697560-A |
| Country | US |
| Kind code | A1 |
| Filing date | Sep 7, 2017 |
| Priority date | Dec 5, 2014 |
| Publication date | Mar 1, 2018 |
| Grant date | — |
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Abstract
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The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a distal end faces an inlet of the mass spectrometer. In other embodiments, the distal end of the probe is 5 mm or less from an inlet of the mass spectrometer.
First claim
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1 - 20 . (canceled) 21 . A system comprising: a mass spectrometry probe comprising a porous material; a probe holder; and a mass spectrometer, wherein the system operates without an application of voltage to the probe. 22 . The system according to claim 21 , wherein the probe is oriented such that the porous material faces an inlet of the mass spectrometer and a distal end of the porous material is 5 mm or less from the inlet of the mass spectrometer. 23 . The system according to claim 22 , wherein the distal end comprises a tip comprised of the porous material. 24 . The system according to claim 21 , wherein the porous material is paper. 25 . The system according to claim 24 , wherein the paper is filter paper. 26 . The system according to claim 21 , wherein the mass spectrometer is a miniature mass spectrometer. 27 . The system according to claim 21 , further comprising a device for supplying solvent to the mass spectrometry probe. 28 . The system according to claim 25 , wherein a solvent is continuously supplied to the mass spectrometry probe. 29 . The system according to claim 21 , wherein the porous material comprises an internal standard. 30 . The system according to claim 21 , wherein the probe operates without pneumatic assistance. 31 . A method for analyzing a sample, the method comprising: providing a system comprising a mass spectrometry probe comprising a porous material, a probe holder, and a mass spectrometer, wherein the system operates without an application of voltage to the probe; introducing a sample to the mass spectrometry probe; analyzing sample droplets introduced into the mass spectrometer from the mass spectrometry probe. 32 . The method according to claim 31 , wherein the sample is a biological sample. 33 . The method according to claim 32 , wherein the biological sample is a body fluid. 34 . The method according to claim 33 , wherein the body fluid is blood or urine. 35 . The method according to claim 31 , wherein the probe is oriented such that the porous material faces an inlet of the mass spectrometer and a distal end of the porous material is 5 mm or less from the inlet of the mass spectrometer. 36 . The method according to claim 35 , wherein the distal end comprises a tip comprised of the porous material. 37 . The method according to claim 31 , wherein the porous material is paper. 38 . The method according to claim 37 , wherein the paper is filter paper. 39 . The method according to claim 31 , wherein the mass spectrometer is a miniature mass spectrometer. 40 . The method according to claim 31 , further comprising a device for supplying solvent to the mass spectrometry probe.
Assignees
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Classifications
- H01J49/0436Primary
using a membrane permeable to liquids · CPC title
Miniaturised spectrometers, e.g. having smaller than usual scale, integrated conventional components · CPC title
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Frequently asked questions
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- What does patent US2018061620A1 cover?
- The invention generally relates to zero volt mass spectrometry probes and systems. In certain embodiments, the invention provides a system including a mass spectrometry probe including a porous material, and a mass spectrometer (bench-top or miniature mass spectrometer). The system operates without an application of voltage to the probe. In certain embodiments, the probe is oriented such that a…
- Who is the assignee on this patent?
- Purdue Research Foundation
- What technology area does this patent fall under?
- Primary CPC classification H01J49/0436. Mapped technology areas include Electricity.
- When was this patent published?
- Publication date Thu Mar 01 2018 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).