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Nitrilase from arabis alpina, its encoding gene, vector, recombinant bacterial strain and uses thereof
US2017355975A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2017355975-A1 |
| Application number | US-201715687700-A |
| Country | US |
| Kind code | A1 |
| Filing date | Aug 28, 2017 |
| Priority date | Aug 27, 2015 |
| Publication date | Dec 14, 2017 |
| Grant date | — |
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Abstract
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The disclosure provides a nitrilase from Arabis alpina , which belongs to genus Arabis , family brassicaceae. The disclosure further provides the encoding gene, vector, recombinant bacterial strain, and the application in the manufacturing of (S)-3-cyano-5-methylhexanoic acid. The wet resting cells containing nitrilase Aa-Nit can kinetically resolve racemic IBSN at 1.2 M with a 42% conversion rate in 15 hr and >99% ee value. The disclosure provides a regio- and stereoselective method for the preparation of (S)-3-cyano-5-methylhexanoic acid. This method provides an atom economical, mild, environmental friendly industrial method to manufacture (S)-3-cyano-5-methylhexanoic acid.
First claim
Opening claim text (preview).
1 . (canceled) 2 . A nitrilase encoding gene comprising the nucleoside sequence shown in SEQ ID No. 2. 3 . A recombinant vector comprising the nitrilase encoding gene of claim 2 . 4 . A recombinant bacterial strain comprising the recombinant vector of claim 3 . 5 - 8 . (canceled)
Assignees
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Classifications
Nitrilase (3.5.5.1) · CPC title
- C12N9/78Primary
acting on carbon to nitrogen bonds other than peptide bonds (3.5) · CPC title
Nitriles (-CN) · CPC title
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- What does patent US2017355975A1 cover?
- The disclosure provides a nitrilase from Arabis alpina , which belongs to genus Arabis , family brassicaceae. The disclosure further provides the encoding gene, vector, recombinant bacterial strain, and the application in the manufacturing of (S)-3-cyano-5-methylhexanoic acid. The wet resting cells containing nitrilase Aa-Nit can kinetically resolve racemic IBSN at 1.2 M with a 42% conversion…
- Who is the assignee on this patent?
- Univ Zhejiang Technology, Zhejiang Chiral Medicine Chemicals Co Ltd
- What technology area does this patent fall under?
- Primary CPC classification C12N9/78. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Dec 14 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).