Database and data processing system for use with a network-based personal genetics services platform

Patent metadata

Field	Value
Publication number	US-2017329904-A1
Application number	US-201615151404-A
Country	US
Kind code	A1
Filing date	May 10, 2016
Priority date	Nov 23, 2011
Publication date	Nov 16, 2017
Grant date	—

Abstract

Databases and data processing systems for use with a network-based personal genetics services platform may include member information pertaining to a plurality of members of the network-based personal genetics services platform. The member information may include genetic information, family history information, environmental information, and phenotype information of the plurality of members. A data processing system may determine, based at least in part on the member information, a model for predicting a phenotype from genetic information, family history information, and environmental information, wherein determining the model includes training the model using the member information pertaining to a set of the plurality of members. The data processing system may also receive a request from a questing member to predict a phenotype of interest, and apply an individual's genetic information, family history information, and environmental information to the model to obtain a prediction associated with the phenotype of interest for the requesting member.

First claim

1 - 2 . (Canceled)

3 . An Internet-based computer system comprising:
a plurality of member computers configured to:
receive, from a plurality of members of a personal genetics service, member input including member family history information, member environmental information, and member phenotype information; and
send the member family history information, the member environmental information, and the member phenotype information over the Internet; and
one or more server computers comprising: a network interface device, one or more processors, and one or more mass storage devices, wherein
the one or more mass storage devices having stored thereon one or more databases comprising member genetic information collected from the plurality of members, as well as the member family history information, the member environmental information, and the member phenotype information sent over the Internet; and
the one or more processors are configured to:
(a) generate a phenotype prediction model by:
retrieving, from the one or more databases, the member genetic information, the member family history information, the member environmental information, and the member phenotype information of the plurality of members; and
generating, using the retrieved information of the plurality of members, one or more models, wherein each of the one or more models is configured to receive as inputs genetic information, family history information, and environmental information of an individual and provide as an output a prediction of the individual having or developing a phenotype; and

(b) apply the phenotype prediction model to a requesting member by:
receiving, through the network interface, a request from the requesting member to make a prediction about a phenotype of interest of the requesting member;
retrieving, from the one or more databases, member genetic information, member family history information, and member environmental information about the requesting member;
inputting the retrieved information about the requesting member to one of the one or more models; and
outputting a prediction of the phenotype of interest of the requesting member using the one of the one or more models.

Assignees

• 23Andme Inc

Inventors

• Naughton Brian Thomas
• Do Chuong
• Macpherson John Michael

Classifications

• G16H10/60

  for patient-specific data, e.g. for electronic patient records · CPC title

• G16B20/00

  ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations · CPC title

• G16B50/00

  ICT programming tools or database systems specially adapted for bioinformatics · CPC title

• G16H50/30

  for calculating health indices; for individual health risk assessment · CPC title

• G06F16/284 Primary

  Relational databases · CPC title