Magnetic beta-tricalcium phosphate spherical particles and method for producing the same

Patent metadata

Field	Value
Publication number	US-2017323709-A1
Application number	US-201715494428-A
Country	US
Kind code	A1
Filing date	Apr 21, 2017
Priority date	May 3, 2016
Publication date	Nov 9, 2017
Grant date	—

Abstract

The present disclosure provides a method for producing beta-tricalcium phosphate spherical particles containing magnetic ions. The method includes mixing acidic amino acid monomers, metal salt of magnetic ions and metal salt of calcium ions in de-ionized water to form a first solution; dissolve phosphate in de-ionized water to form a second solution; mixing the first and second solutions to form a third solution; and performing hydrothermal synthesis of the third solution.

First claim

1 . A method for producing beta-tricalcium phosphate spherical particles containing magnetic ions, the method comprising:
mixing acidic amino acid monomers, metal salt of the magnetic ions and metal salt of calcium ions in de-ionized water to form a first solution; dissolve phosphate in de-ionized water to form a second solution; mixing the first and second solutions to form a third solution; and performing hydrothermal synthesis of the third solution.

2 . The method of claim 1 , wherein amino acid in the acidic amino acid monomer includes at least one selected from a group consisting of aspartic acid and glutamic acid.

3 . The method of claim 1 , further comprising adjusting a pH of the third solution, wherein the adjusted pH thereof is in a range of 4 to 8.

4 . The method of claim 1 , wherein the hydrothermal synthesis is carried out at a temperature of 100 to 230° C. for 6 to 24 hours.

5 . The method of claim 1 , wherein the magnetic ions are selected from Fe, Co, or Ni ions.

6 . The method of claim 1 , wherein the magnetic ions are Fe ions, and a molar ratio of Fe to (Fe+Ca) in the third solution is in a range of 0.1 to 0.3, and the metal salt of Fe ions includes at least one selected from a group consisting of FeCl 2 , FeCl 3 , Fe(NO 3 ) 2 , Fe(NO 3 ) 3 , Fe(OH) 2 and Fe(OH) 3 .

7 . The method of claim 1 , wherein the metal salt of calcium ions includes at least one selected from Ca(NO 3 ) 2 , CaCl 2 , Ca(OH) 2 and (Ca(CH 3 CO 2 ) 2 .

8 . The method of claim 1 , wherein the phosphate includes at least one selected from H 3 PO 4 , NaH 2 PO 4 , Na 2 HPO 4 , KH 2 PO 4 , K 2 HPO 4 , (NH 4 )H 2 PO 4 and (NH 4 ) 2 HPO 4 .

9 . A method for producing beta-tricalcium phosphate spherical particles being magnetic, the method comprising:
mixing acidic amino acid monomers, metal salt of magnetic ions and metal salt of calcium ions in de-ionized water to form a first solution; dissolve phosphate in de-ionized water to form a second solution; mixing the first and second solutions to form a third solution; performing hydrothermal synthesis of the third solution to form beta-tricalcium phosphate spherical particles containing magnetic ions; and performing thermal treatment of the beta-tricalcium phosphate spherical particles containing magnetic ions.

10 . The method of claim 9 , wherein the thermal treatment is performed at a temperature above 600° C. inclusive under a reduction atmosphere.

11 . The method of claim 9 , wherein the thermal treatment includes first and subsequent second thermal treatments, wherein the first thermal treatment is performed at a temperature above 600° C. inclusive under a reduction atmosphere, wherein the second treatment is performed under an oxygen atmosphere.

12 . The method of claim 9 , wherein amino acid in the acidic amino acid monomer includes at least one selected from a group consisting of aspartic acid and glutamic acid.

13 . The method of claim 9 , further comprising adjusting a pH of the third solution, wherein the adjusted pH thereof is in a range of 4 to 8.

14 . The method of claim 9 , wherein the hydrothermal synthesis is carried out at a temperature of 100 to 230° C. for 6 to 24 hours.

15 . The method of claim 9 , wherein the magnetic ions are selected from Fe, Co, or Ni ions.

16 . The method of claim 15 , wherein the magnetic ions are Fe ions, and a molar ratio of Fe to (Fe+Ca) in the third solution is in a range of 0.1 to 0.3.

17 . The method of claim 16 , wherein the metal salt of Fe ions includes at least one selected from a group consisting of FeCl 2 , FeCl 3 , Fe(NO 3 ) 2 , Fe(NO 3 ) 3 , Fe(OH) 2 and Fe(OH) 3 .

18 . The method of claim 9 , wherein the metal salt of calcium ions includes at least one selected from Ca(NO 3 ) 2 , CaCl 2 , Ca(OH) 2 and (Ca(CH 3 CO 2 ) 2 .

19 . The method of claim 9 , wherein the phosphate includes at least one selected from H 3 PO 4 , NaH 2 PO 4 , Na 2 HPO 4 , KH 2 PO 4 , K 2 HPO 4 , (NH 4 )H 2 PO 4 and (NH 4 ) 2 HPO 4 .

Assignees

• Research & Business Found Sungkyunkwan Univ
• Univ Sungkyunkwan Res Business Found

Inventors

• Jung Hyun Suk
• Park So Yeon
• Lee Dong Geon
• Jin Young Un
• Kim Min Hee

Classifications

• C01B25/32 Primary

  Phosphates of magnesium, calcium, strontium, or barium · CPC title

• C04B2235/44

  Metal salt constituents or additives chosen for the nature of the anions, e.g. hydrides or acetylacetonate · CPC title

• C04B2235/3208

  Calcium oxide or oxide-forming salts thereof, e.g. lime · CPC title

• C04B2235/443

  Nitrates or nitrites · CPC title

• C04B2235/444

  Halide containing anions, e.g. bromide, iodate, chlorite · CPC title