Systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer

Patent metadata

Field	Value
Publication number	US-2017312795-A1
Application number	US-201715496355-A
Country	US
Kind code	A1
Filing date	Apr 25, 2017
Priority date	Apr 29, 2016
Publication date	Nov 2, 2017
Grant date	—

Abstract

The invention generally relates to systems with anti-fouling control and methods for controlling fouling within a channel of a plug flow crystallizer. In certain aspects, the invention provides a system that includes a plug flow crystallizer having a channel, one or more heating/cooling elements, each operably associated with a different segment of the channel, and a controller. The controller is operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel. In certain embodiments, these segments may be cyclically alternated, in that the segment in which crystal grows in one cycle becomes the segment in which crystal dissolves in the next cycle and vice versa, to realize a fully continuous crystallization process.

First claim

What is claimed is:

1 . A system with anti-fouling control, the system comprising:
a plug flow crystallizer comprising a channel; one or more heating/cooling elements, each operably associated with a different segment of the channel; and a controller operably coupled to the one or more heating/cooling elements and configured to implement a temperature profile within the channel of the plug flow crystallizer that grows crystals in a plug of fluid that flows through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plug of fluid in the second segment of the channel.

2 . The system according to claim 1 , wherein the first segment of the channel has a same length as the second segment of the channel.

3 . The system according to claim 2 , wherein the temperature profile in the first segment is configured for cooling the one or more plugs of fluid that flow in the first segment to thereby cause crystal growth.

4 . The system according to claim 3 , wherein the temperature profile in the second segment is configured for heating the one or more plugs of fluid that flow in the second segment to thereby cause encrust dissolution while having minimal impact on crystal growth in the one or more plugs of fluid in the second segment of the channel.

5 . The system according to claim 1 , wherein the controller is further configured to calculate the temperature profile based on encrust kinetics and crystal growth kinetics for a particular reaction.

6 . The system according to claim 1 , further comprising one or more sensors operably coupled to the system.

7 . The system according to claim 6 , wherein a first sensor determines a period of output stream collection for as long as flow is within a predetermined product quality range.

8 . The system according to claim 7 , wherein the first sensor operably communicates to the controller, which manipulates a valve based on data received from the first sensor, to control collection of the one or more plugs of fluid.

9 . The system according to claim 6 , wherein a second sensor monitors encrust within the channel.

10 . The system according to claim 9 , wherein the second sensor operably communicates to the controller, which manipulates the temperature within the channel, via the one or more heating/cooling elements, based on data received from the second sensor.

11 . A method for controlling fouling within a channel of a plug flow crystallizer, the method comprising:
flowing one or more plugs of fluid through a channel of a plug flow crystallizer; and implementing, via controller operably coupled to the plug flow crystallizer, a temperature profile within the channel of the plug flow crystallizer that grows crystals in the one or more plugs of fluid that are flowing through a first segment of the channel and dissolves encrust in a second segment of the channel while having minimal impact on crystal growth in the plugs of fluid in the second segment of the channel.

12 . The method according to claim 11 , wherein the first segment of the channel has a same length as the second segment of the channel.

13 . The method according to claim 12 , wherein the temperature profile in the first segment is configured for cooling the one or more plugs of fluid that flow in the first segment to thereby cause crystal growth.

14 . The method according to claim 13 , wherein the temperature profile in the second segment is configured for heating the one or more plugs of fluid that flow in the second segment to thereby cause encrust dissolution while having minimal impact on crystal growth in the one or more plugs of fluid in the second segment of the channel.

15 . The method according to claim 11 , wherein the method further comprises calculating, via the controller, the temperature profile based on heat transfer, encrust kinetics and crystal growth kinetics for a particular crystallization reaction.

16 . The method according to claim 11 , further comprising monitoring conditions within the channel via one or more sensors operably coupled to the controller.

17 . The method according to claim 16 , wherein a first sensor determines a period of output stream collection for as long as flow is within a predetermined product quality range.

18 . The method according to claim 17 , wherein the first sensor operably communicates to the controller, which manipulates a valve based on data received from the first sensor, to control collection of the one or more plugs of fluid.

19 . The method according to claim 16 , wherein a second sensor monitors encrust within the channel.

20 . The method according to claim 19 , wherein the second sensor operably communicates to the controller, which manipulates the temperature within the channel, via one or more heating/cooling elements, based on data received from the second sensor.

Assignees

• Purdue Research Foundation

Inventors

• Koswara Andy
• Nagy Zoltan Kalman

Classifications

• C30B29/54 Primary

  Organic compounds · CPC title

• B01D9/0077

  Screening for crystallisation conditions or for crystal forms · CPC title

• B08B7/0064

  by temperature changes · CPC title

• B01D9/0063

  Control or regulation (control per se G05) · CPC title

• B01D9/0072

  Crystallisation in microfluidic devices · CPC title