Probe Adaptor Assembly

Patent metadata

Field	Value
Publication number	US-2017294296-A1
Application number	US-201715464924-A
Country	US
Kind code	A1
Filing date	Mar 21, 2017
Priority date	Apr 11, 2016
Publication date	Oct 12, 2017
Grant date	—

Abstract

An apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer is disclosed. The apparatus comprises: an attachment member for releasably attaching a probe assembly to the apparatus; a cap for enclosing the attachment member; wherein the apparatus is operable to deliver a voltage to a probe assembly only when the cap is arranged to enclose the attachment member; and wherein the cap is configurable to enclose the attachment member when a probe assembly is attached to the apparatus.

First claim

1 . An apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer, the apparatus comprising:
an attachment member for releasably attaching a probe assembly to the apparatus; a cap for enclosing the attachment member; wherein the apparatus is operable to deliver a voltage to a probe assembly only when the cap is arranged to enclose the attachment member; and wherein the cap is configurable to enclose the attachment member when a probe assembly is attached to the apparatus.

2 . The apparatus of claim 1 , wherein the cap is configurable to enclose the attachment member when no probe assembly is attached to the apparatus so as to prevent a probe assembly being brought into contact with the attachment member.

3 . The apparatus of claim 1 , wherein:
the apparatus comprises an orifice; the apparatus is configured such that the probe assembly is insertable into the orifice; and the attachment member is configurable to releasably secure the probe assembly within the orifice.

4 . The apparatus of claim 1 , wherein the attachment member comprises or is in electrical connection with an electrical contact for delivering the voltage from the apparatus to the probe assembly when the probe assembly is releasably attached to the apparatus.

5 . The apparatus of claim 1 , where the cap comprises an aperture through which at least a portion of the probe assembly can pass.

6 . The apparatus of claim 5 , wherein the apparatus comprises a device configured to close the aperture when the cap is arranged to enclose the attachment member and when no probe assembly is attached to the apparatus.

7 . The apparatus of claim 6 , wherein the device is configured such that the aperture is openable, in use, only when the attachment member is not enclosed by the cap.

8 . The apparatus of claim 6 , wherein the device comprises one or more balls or other objects and one or more pockets for receiving the one or more balls or other objects.

9 . The apparatus of claim 1 , further comprising:
a probe tip configured to receive a capillary of the probe assembly; and a device for controlling the position of the capillary relative to the probe tip.

10 . An apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer, the apparatus comprising:
an attachment member for releasably attaching a probe assembly to the apparatus; a probe tip configured to receive a capillary of the probe assembly; and a control device for controlling the position of the capillary relative to the probe tip.

11 . The apparatus of claim 9 , wherein the device is configured such that the position remains substantially unaltered when a probe assembly is detached from and/or attached to the apparatus.

12 . The apparatus as claimed in claim 9 , wherein:
the probe tip comprises a capillary configured to receive the capillary of the probe assembly; and the control device is configured to control the position of the capillary relative to the probe tip capillary.

13 . The apparatus as claimed in claim 9 , further comprising a guiding member configured to guide the capillary into the probe tip capillary when the probe assembly is releasably attached to the apparatus.

14 . The apparatus as claimed in claim 9 , wherein:
the apparatus comprises a cap for enclosing the attachment member; the attachment member is provided in a main body of the apparatus; and the cap is releasably securable to the main body so as to enclose the attachment member.

15 . The apparatus as claimed in claim 14 , wherein the control device is operable from an external surface of the cap.

16 . The apparatus as claimed in claim 14 , wherein:
the control device comprises a first mechanism in the cap that is engagable with a second mechanism in the main body; wherein operation of the control device causes the position of the capillary relative to the probe tip to be altered via the first and second mechanisms.

17 . The apparatus as claimed in claim 16 , wherein the first and/or second mechanisms are configured such that the position of the capillary relative to the probe tip remains substantially unaltered when the cap is secured to and/or released from the main body.

18 . The apparatus as claimed in claim 1 , further comprising:
a liquid drain; and a device for collecting liquid incident upon at least a portion of the apparatus and for directing the liquid to the drain.

19 . The apparatus as claimed in claim 18 , wherein the drain comprises one or more open-ended slots or indentations.

20 . The apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer, the apparatus comprising:
an attachment member for releasably attaching a probe assembly to the apparatus; a liquid drain; and a device for collecting liquid incident upon the apparatus and for directing the liquid to the liquid drain; wherein the drain comprises one or more open-ended slots or indentations.

21 . Apparatus as claimed in claim 19 , further comprising one or more fins, ridges, bumps or other protrusions configured to prevent blockage of the drain.

22 . Apparatus as claimed in claim 19 , wherein the position and/or orientation of the drain can be fixed.

23 . An adaptor for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer, the adaptor comprising apparatus as claimed in claim 1 .

24 . A mass and/or ion mobility spectrometer comprising apparatus as claimed in claim 1 .

25 . A method of delivering eluent to a mass and/or ion mobility spectrometer comprising:
providing a probe assembly; providing an apparatus for connecting an ionisation probe assembly to a mass and/or ion mobility spectrometer, the apparatus including an attachment member for releasably attaching a probe assembly to the apparatus, a cap for enclosing the attachment member, wherein the apparatus is operable to deliver a voltage to a probe assembly only when the cap is arranged to enclose the attachment member, and wherein the cap is configurable to enclose the attachment member when a probe assembly is attached to the apparatus; releasably attaching the probe assembly to the apparatus using the attachment member; and supplying eluent to the probe assembly such that eluent is transmitted through the probe assembly into the spectrometer.

Assignees

• Micromass Ltd

Inventors

• Trivett Ian
• O'Brien Stephen
• Dutton Graeme

Classifications

• H01J49/0422 Primary

  for gaseous samples (interfaces to gas chromatographs G01N30/7206) · CPC title

• F16L15/08

  with supplementary elements (F16L15/04 takes precedence) · CPC title

• G01N30/7233

  interfaced to liquid or supercritical fluid chromatograph (interfaces in general for introducing or extracting samples to be analysed with specially adapted mass spectrometer, see H01J49/04) · CPC title

• G01N30/7266

  by electric field, e.g. electrospray · CPC title

• H01J49/167

  Capillaries and nozzles specially adapted therefor; (electrostatic spraying per se B05B5/00) · CPC title