AQUEOUS ETHYLCELLULOSE DISPERSIONS With polymeric additive

Patent metadata

Field	Value
Publication number	US-2017292010-A1
Application number	US-201515512860-A
Country	US
Kind code	A1
Filing date	Sep 28, 2015
Priority date	Sep 30, 2014
Publication date	Oct 12, 2017
Grant date	—

Abstract

Provided is an aqueous composition having pH of 8 or higher and comprising (a) a solid phase comprising dispersed particles that comprise an amount of ethylcellulose polymer, (b) an amount of one or more polymeric dispersants, wherein said polymeric dispersant has a weight-average molecular weight of 5,000 daltons or higher, and wherein said polymeric dispersant has an acid value of 60 to 190 mg KOH/g of polymer. Also provided is a method of making such a composition using an extruder. Also provided is a film made by removing water from such a composition.

First claim

1 . An aqueous composition having pH of 8 or higher and comprising
(a) a solid phase comprising dispersed particles that comprise an amount of ethylcellulose polymer, (b) an amount of one or more polymeric dispersants, wherein said polymeric dispersant has a weight-average molecular weight of 5,000 daltons or higher, and wherein said polymeric dispersant has an acid value of 60 to 190 mg KOH/g of polymer.

2 . The aqueous composition of claim 1 wherein said composition comprises monomeric dispersant in an amount of 0 to 0.01% by weight based on the weight of said composition.

3 . The aqueous composition of claim 1 wherein said polymeric dispersant comprises one or more olefin copolymers, one or more monoester derivatives of cellulose, or a mixture thereof.

4 . A method of making the aqueous composition of claim 1 , wherein said method comprises
(i) feeding the ethylcellulose polymer and the polymeric dispersant into a melt and mix zone of an extruder wherein the ethylcellulose polymer and the polymeric dispersant are heated and mixed together to form a melt; (ii) conveying the melt to an emulsification zone of the extruder in which the temperature and pressure are controlled; (iii) feeding a base and water into the emulsification zone wherein the melt is dispersed to form an emulsion having 60% to 72% solids by volume; (iv) conveying the emulsion to a dilution and cooling zone of the extruder; and feeding water into the dilution and cooling zone to dilute the high internal phase emulsion thereby forming the aqueous composition.

5 . The method of claim 3 , wherein said base is a fugitive base.

6 . A film made by a process comprising removing water from the aqueous composition of claim 1 .

7 . The film of claim 5 wherein said film is on the surface of or encapsulating or enveloping a multiparticulate.

8 . The film of claim 5 wherein said film is on the surface of a pharmaceutical tablet or pharmaceutical capsule.

Assignees

• Dow Global Technologies Llc

Inventors

• Malotky David L
• Workentine Shari L
• Rogers True L
• Dean Stacey L
• Crimmins Matthew J

Classifications

• C08L2203/16

  used for films · CPC title

• A61K9/4866

  Organic macromolecular compounds · CPC title

• C08J5/18

  Manufacture of films or sheets · CPC title

• C08L1/28 Primary

  Alkyl ethers · CPC title

• C08J2301/28

  Alkyl ethers · CPC title