Multiple variants of meningococcal protein nmb1870

Patent metadata

Field	Value
Publication number	US-2017290902-A1
Application number	US-201615351286-A
Country	US
Kind code	A1
Filing date	Nov 14, 2016
Priority date	Nov 22, 2002
Publication date	Oct 12, 2017
Grant date	—

Abstract

Meningococcal protein NMB 1870 has been described in the prior art. The inventors have found that NMB 1870 is an effective antigen for eliciting anti-meningococcal antibody responses, and that it is expressed across all meningococcal serogroups. Forty-two different NMB 1870 sequences have been identified, and these group into three variants. Serum raised against a given variant is bactericidal within the same variant group, but is not active against strains which express one of the other two variants i.e. there is intra-variant cross-protection, but not inter-variant cross-protection. For maximum cross-strain efficacy, therefore, the invention uses mixture comprising different variants of NMB 1870.

First claim

1 : A composition comprising at least two of the following antigens: (a) a first protein, comprising an amino acid sequence having at least 85% sequence identity to SEQ ID NO: 24 and/or comprising an amino acid sequence consisting of a fragment of at least 7 contiguous amino acids from SEQ ID. NO: 24; (b) a second protein, comprising an amino acid sequence having at least 85% sequence identity to SEQ ID NO: 33 and/or comprising an amino acid sequence consisting of a fragment of at least 7 contiguous amino acids from SEQ ID NO: 33; and (c) a third protein, comprising an amino acid sequence having at least 85% sequence identity to SEQ ID NO: 41 and/or comprising an amino acid sequence consisting of a fragment of at least 7 contiguous amino acids from SEQ ID NO: 41.

2 - 33 . (canceled)

Assignees

• Glaxosmithkline Biologicals Sa

Inventors

• Comanducci Maurizio
• Pizza Mariagrazia

Classifications

• C07K14/285

  from Pasteurellaceae (F), e.g. Haemophilus influenza · CPC title

• A61K39/095 Primary

  Neisseria · CPC title

• C07K14/22

  from Neisseriaceae (F) · CPC title

• A61K39/102

  {Pasteurellales, e.g. Actinobacillus}, Pasteurella; Haemophilus · CPC title

• A61K39/39

  characterised by the immunostimulating additives, e.g. chemical adjuvants · CPC title