Method for phosgenating compounds containing hydroxyl, thiol, amino and/or formamide groups

Patent metadata

Field	Value
Publication number	US-2017274346-A1
Application number	US-201515503855-A
Country	US
Kind code	A1
Filing date	Aug 17, 2015
Priority date	Aug 20, 2014
Publication date	Sep 28, 2017
Grant date	—

Abstract

The invention relates to a method particularly for reacting phosgene with compounds that contain hydroxyl, thiol, amino and/or formamide groups, comprising the steps of: (I) providing a reactor which has a first reaction chamber ( 300, 310, 320, 330, 340, 350 ) and a second reaction chamber ( 200, 210, 220, 230, 240, 250, 260 ), the first and the second reaction chambers being separated from one another by means of a porous carbon membrane ( 100, 110, 120, 130, 140, 150 ); (II) providing carbon monoxide and chlorine in the first reaction chamber; and simultaneously (III) providing a compound containing hydroxyl, thiol, amino and/or formamide groups in the second reaction chamber. The porous carbon membrane is configured to catalyse the reaction of carbon monoxide and chlorine to obtain phosgene, and to allow this formed phosgene to pass into the second reaction chamber. The invention also relates to a reactor that is suitable for carrying out the claimed method.

First claim

1 . A method of reacting a first compound with a second compound,
wherein the first compound has a GHS hazard identification of GHS06 and is obtainable from the reaction of at least one first fluid precursor compound and a second fluid precursor compound and wherein the second compound is capable of a chemical reaction with the first compound, said method comprising: (I) providing a reactor comprising a first reaction space, wherein the first and second reaction spaces are separated from one another by a porous carbon membrane; (II) providing the first and second precursor compounds in the first reaction space; and simultaneously (III) providing the second compound in the second reaction space; wherein the porous carbon membrane is set up to:
catalyze the reaction of the first and second precursor compounds to give the first compound and
allow the first compound formed to move into the second reaction space.

2 . The method as claimed in claim 1 , wherein the first compound is phosgene, the first precursor compound is carbon monoxide, the second precursor compound is chlorine and the second compound is a compound containing one or more hydroxyl, thiol, amino and/or formamide groups.

3 . The method as claimed in claim 1 , wherein the porous carbon membrane has a nominal pore size, determined by mercury porosimetry (ISO 15901-1), of ≧0.01 to ≦10 μm.

4 . The method as claimed in claim 1 , wherein the porous carbon membrane further comprises a catalyst for reaction of the first compound with the second compound, arranged at least partly on a side of the porous carbon membrane facing the second reaction space.

5 . The method as claimed in claim 1 , wherein a homogeneous catalyst is additionally present in the second reaction space.

6 . The method as claimed in claim 1 , wherein an open-cell foam is additionally present in the first reaction space.

7 . The method as claimed in claim 1 , wherein the reactor further comprises a cavity to accommodate a heat transfer fluid.

8 . The method as claimed in claim 1 , wherein the reactor additionally comprises a dwell zone to complete the reaction of the first compound with the second compound.

9 . The method as claimed in claim 1 , wherein the reactor comprises a multitude of first reaction spaces second reaction spaces and porous carbon membranes, wherein one first and one second reaction space are separated from one another in each case by a porous carbon membrane.

10 . The method as claimed in claim 1 , wherein the reactor has a cylindrical construction with first reaction space and second reaction space arranged concentrically from the inside outward, wherein the first and second reaction spaces are separated from one another by the porous carbon membrane.

11 . The method as claimed in claim 1 , wherein the first reaction space and/or the second reaction space have a cross-sectional area at right angles to the flow direction of the fluid flowing through of ≧8·10 −5 to ≦8·10 −4 m 2 .

12 . The method as claimed in claim 1 , wherein the reactor comprises a multitude of first reaction spaces surrounded by a common second reaction space.

13 . A reactor for reaction of phosgene with one or more compounds containing one or more hydroxyl, thiol, amino and/or formamide groups, comprising:
a first reaction space and a second reaction space, wherein the first and second reaction spaces are separated from one another by a porous carbon membrane;
and
a catalyst for the reaction of phosgene with the compound containing hydroxyl, thiol, amino and/or formamide groups, arranged at least partly on the side of the porous carbon membrane facing the second reaction space.

14 . The reactor as claimed in claim 13 , wherein an open-cell foam is additionally present in the first reaction space.

15 . The reactor as claimed in claim 13 , wherein the reactor comprises a multitude of first reaction spaces surrounded by a common second reaction space.

Assignees

• Bayer Ag

Inventors

• Mleczko Leslaw
• Wolf Aurel
• Schellen Ralf
• Metaxas Konstantinos
• Roggan Jens Stefan

Classifications

• B01J19/0013 Primary

  Controlling the temperature of the process · CPC title

• C01B31/28

  Chemistry & Metallurgy · mapped topic

• C07C263/10

  by reaction of amines with carbonyl halides, e.g. with phosgene · CPC title

• C01B31/18

  Chemistry & Metallurgy · mapped topic

• B01J31/0231

  Halogen-containing compounds · CPC title