Method for the phosgenation of compounds comprising hydroxyl, thiol, amino and/or formamide groups

Patent metadata

Field	Value
Publication number	US-2017274341-A1
Application number	US-201515503944-A
Country	US
Kind code	A1
Filing date	Aug 18, 2015
Priority date	Aug 20, 2014
Publication date	Sep 28, 2017
Grant date	—

Abstract

A method of reacting a first compound with a second compound, wherein the first compound has a GHS hazard identification of GHS06 and is obtainable from the reaction of at least one first fluid precursor compound and one second fluid precursor compound and wherein the second compound is capable of a chemical reaction with the first compound is provided

First claim

1 . A method of reacting a first compound with a second compound,
wherein the first compound has a GHS hazard identification of GHS06 and is obtainable from the reaction of at least one first fluid precursor compound and one second fluid precursor compound and wherein the second compound is capable of a chemical reaction with the first compound, comprising: (I) providing a liquid phase containing the second compound in a reactor having an upper end and a lower end viewed in the direction of gravity; (II) providing a contact tube having an upper end and a lower end in the reactor, wherein
the lower end of the contact tube is immersed into the liquid phase containing the second compound and
a catalyst bed present in the contact tube is set up to catalyze the reaction between the first and second precursor compounds to give the first compound;
(III) introducing the first and second precursor compounds through the contact tube, with the first compound formed in the contact tube exiting from the lower end of the contact tube and coming into contact with liquid phase containing the second compound.

2 . The method as claimed in claim 1 , wherein the first compound is phosgene, the first precursor compound is carbon monoxide, the second precursor compound is chlorine, the catalyst present in the catalyst bed is an activated carbon catalyst and the second compound is a compound containing one or more of hydroxyl, thiol, amino and/or formamide groups.

3 . The method as claimed in claim 2 , wherein the activated carbon catalyst has a BET surface area of ≧300 to ≦2000 m 2 /g and a d 90 of the particle size distribution of 25 μm to 4 mm.

4 . The method according to claim 1 , wherein the method is conducted in a reactor comprising:
a hood at the upper end of the reactor, bounded by a tube plate within the reactor; a multitude of contact tubes arranged in longitudinal direction of the reactor, the contact tubes being secured on the tube plate by upper ends thereof;
and wherein the liquid phase containing the second compound is provided in an interspace around the contact tubes.

5 . The method as claimed in claim 1 , wherein a catalyst is additionally present in the liquid phase containing the second compound.

6 . The method as claimed in claim 1 , wherein the contact tube(s) has/have a ratio of length to diameter of ≧15:1 to ≦1600:1.

7 . The method as claimed in claim 1 , wherein the sum total of the partial pressures of the first precursor compound and the second precursor compound is ≧1 bar to ≦26 bar.

8 . A reactor for reaction of phosgene with one or more compounds containing one or more hydroxyl, thiol, amino and/or formamide groups, comprising:
a hood at the upper end of the reactor, bounded by a tube plate within the reactor; a multitude of contact tubes arranged in longitudinal direction of the reactor, the contact tubes being secured on the tube plate by upper ends thereof, wherein a catalyst bed present in the contact tubes is set up to catalyze the reaction of carbon monoxide and chlorine; the reactor is set up to introduce carbon monoxide and chlorine gas into space formed between the hood and tube plate, such that these gases flow through the contact tubes; the reactor is set up to introduce a compound containing one or more hydroxyl, thiol, amino and/or formamide groups into an interspace around the contact tubes and to withdraw one or more liquid reaction products of said compound with phosgene from said interspace and the reactor is additionally set up to withdraw one or more gaseous reaction products on a side of the tube plate facing away from the hood.

9 . The reactor as claimed in claim 8 , wherein activated carbon catalyst utilized therein has a BET surface area of ≧300 to ≦2000 m 2 /g and a d 90 of the particle size distribution of 25 μm to 4 mm.

10 . The reactor as claimed in claim 8 , wherein the contact tubes have a ratio of length to diameter of ≧15:1 to ≦1600:1.

Assignees

• Bayer Ag

Inventors

• Roggan Jens Stefan
• Mleczko Leslaw
• Metaxas Konstantinos
• Gottfried Michael
• Peckermann Iija
• Schubert Stephan
• Barth Ekkehard

Classifications

• B01J8/06

  in tube reactors; the solid particles being arranged in tubes · CPC title

• B01J2219/0004

  Processes in series · CPC title

• C01B32/80

  Phosgene · CPC title

• B01J2219/00058

  Temperature measurement · CPC title

• C07C68/02 Primary

  from phosgene or haloformates · CPC title