Methods and Systems of Generating Rapidly Varying Pressure Amplitudes in Fluidic Circuits in a Dialysis Treatment System

Patent metadata

Field	Value
Publication number	US-2017258979-A1
Application number	US-201715453620-A
Country	US
Kind code	A1
Filing date	Mar 8, 2017
Priority date	Mar 8, 2016
Publication date	Sep 14, 2017
Grant date	—

Abstract

The present specification describes a modular, portable hemofiltration system, for providing improved clearance levels of blood toxins, which includes at least one roller pump that is designed and operated to generate a rapidly varying pressure profile of fluid within at least a blood circuit of the hemofiltration system.

First claim

We claim:

1 . A method for providing increasing clearance levels of blood toxins comprising:
providing a portable dialysis system comprising:
a manifold, comprising a plurality of blood and dialysate circuits;
at least one tube segment in fluid communication with at least one of said blood and dialysate circuits;
at least one pump for pumping a fluid through said at least one tube segment and at least one of said plurality of blood and dialysate circuits; and
operating said at least one pump to apply a force to said at least one tube segment to generate fluid flow through said at least one tube segment, wherein said at least one pump is configured to generate said fluid flow with a pressure profile that varies between a positive pressure and a negative pressure within a predetermined period.

2 . The method of claim 1 , wherein said at least one pump comprises a rotor pump having a plurality of rollers.

3 . The method of claim 2 , wherein said rotor pump has a diameter no greater than 4 inches.

4 . The method of claim 2 , wherein said rotor pump has a range of 4 to 6 rollers.

5 . The method of claim 2 , wherein each of said plurality of rollers comprises a plurality of equidistantly spaced cylindrical pins.

6 . The method of claim 5 , wherein said plurality of equidistantly spaced cylindrical pins is in a range of 4 to 6.

7 . The method of claim 1 , wherein said fluid flow is any one of dialysate flow, blood flow, and infusate flow.

8 . The method of claim 1 , wherein a change in pressure amplitude experienced by said fluid flow is at least 100 mmHg and said predetermined period is less than 0.5 seconds.

9 . The method of claim 1 , wherein a change in pressure amplitude experienced by said fluid flow is at least 100 mmHg and said predetermined period is less than 0.05 seconds.

10 . The method of claim 1 , wherein a change in pressure amplitude experienced by said fluid flow is at least 200 mmHg and said predetermined period is less than 0.5 seconds.

11 . The method of claim 1 , wherein a change in pressure amplitude experienced by said fluid flow is at least 200 mmHg and said predetermined period is less than 0.05 seconds.

12 . The method of claim 1 , wherein an amplitude of said pressure profile varies from a positive 100 mmHg, or more, to a negative 25 mmHg, or less, over a period less than 0.5 seconds.

13 . The method of claim 1 , wherein an amplitude of said pressure profile varies from a positive 100 mmHg, or more, to a negative 25 mmHg, or less, over a period less than 0.05 seconds.

14 . The method of claim 1 , wherein an amplitude of said pressure profile varies from a positive 200 mmHg, or more, to a negative 50 mmHg, or less, over a period less than 0.5 seconds.

15 . The method of claim 1 , wherein an amplitude of said pressure profile varies from a positive 300 mmHg, or more, to a negative 100 mmHg, or less, over a period of less than 0.5 seconds.

16 . The method of claim 1 , wherein a pressure amplitude of said fluid flow changes from positive pressure to negative pressure in less than 1 second and wherein a magnitude of the pressure amplitude change increases as the flow rate increases for the corresponding fluid flow.

17 . The method of claim 1 , wherein a pressure amplitude of said fluid flow changes from positive pressure to negative pressure in less than 1 second and a magnitude of the pressure amplitude change decreases as the flow rate decreases for the corresponding fluid flow.

18 . The method of claim 1 , wherein a pressure amplitude of said fluid flow cycles between a positive pressure and a negative pressure at least once in less than 0.5 seconds.

19 . The method of claim 1 , wherein a pressure amplitude of said fluid flow cycles between a positive pressure and a negative pressure at least twice in less than 0.5 seconds.

20 . The method of claim 1 , wherein a pressure amplitude of said fluid flow cycles between a positive pressure and a negative pressure at least three times in less than 0.5 seconds.

21 . The method of claim 1 , further comprising operating said at least one pump to fill said tube segment with said fluid at a first point in time such that said pressure profile reaches a maximum amplitude and operating said at least one pump to expel said fluid from said tube at a second point in time, occurring after said predetermined period, such that said pressure profile reaches a minimum amplitude.

22 . A method for providing increasing clearance levels of blood toxins comprising:
providing a portable dialysis system comprising:
a manifold comprising a blood circuit, wherein said blood circuit has at least one tube segment;
a rotor pump for pumping a blood through said at least one tube segment, wherein said rotor pump has a diameter no greater than 4 inches; and
operating said at least one pump to apply a force to said at least one tube segment to generate blood flow through said at least one tube segment, wherein said at least one pump is configured to generate said blood flow with a pressure profile that varies between a positive pressure and a negative pressure within a predetermined period, wherein an amplitude of said pressure profile varies from a positive 100 mmHg, or more, to a negative 25 mmHg, or less, over a period less than 0.5 seconds and wherein an average pressure of said blood flow remains positive over a period of at least 5 seconds.

23 . A dialysis system for providing increasing clearance levels of blood toxins comprising:
a manifold comprising a blood circuit, wherein said blood circuit has at least one tube segment; a rotor pump in physical communication with said at least one tube segment and configured to pump blood through said at least one tube segment, wherein said rotor pump has a diameter no greater than 4 inches; and a controller configured to operate said at least one pump to apply a force to said at least one tube segment to generate blood flow through said at least one tube segment, wherein said controller is adapted to control the at least one pump to generate said blood flow with a pressure profile that varies between a positive pressure and a negative pressure within a predetermined period.

24 . The dialysis system of claim 23 further comprising a single fluid reservoir having a fluid capacity no greater than 10 liters.

25 . The dialysis system of claim 23 wherein the rotor pump has a range of 4 to 6 rollers.

26 . The dialysis system of claim 23 wherein said blood toxins include compositions having a molecular weight greater than 500 Daltons.

27 . The dialysis system of claim 23 , wherein a change in pressure amplitude experienced by said blood flow is at least 100 mmHg and said predetermined period is less than 0.5 seconds.

28 . The dialysis system of claim 23 , wherein a change in pressure amplitude experienced by said blood flow is at least 100 mmHg and said predetermined period is less than 0.05 seconds.

29 . The dialysis system of claim 23 , wherein a change in pressure amplitude experienced by said blood flow is at least 200 mmHg and said predetermined period is less than 0.5 seconds.

30 . The dialysis system of claim 23 , wherein a change in pressure amplitude experienced by said blood flow is at least 200 mmHg and said predetermined period is less than 0.05 seconds.

Assignees

• Fresenius Medical Care Holdings Inc

Inventors

• Fulkerson Barry Neil
• Pham Nhan Viet
• Huang Alec

Classifications

• A61M60/50

  Details relating to control · CPC title

• A61M60/279

  Peristaltic pumps, e.g. roller pumps · CPC title

• A61M1/3672 Primary

  Means preventing coagulation · CPC title

• A61M1/3455

  Substitution fluids · CPC title

• A61M1/341

  by measuring the filtrate rate or volume · CPC title