Use of peba having long blocks for the manufacture of all or part of a catheter

Patent metadata

Field	Value
Publication number	US-2017232152-A1
Application number	US-201515303077-A
Country	US
Kind code	A1
Filing date	Apr 13, 2015
Priority date	Apr 11, 2014
Publication date	Aug 17, 2017
Grant date	—

Abstract

A copolymer containing polyether blocks and polyamide blocks for manufacturing an inflatable catheter element, such as a catheter balloon, with improved bursting strength, in which said copolymer has the following characteristics: number-average molecular mass of the PE blocks greater than 500 g/mol, and number-average molecular mass of the PA blocks greater than 10 000 g/mol.

First claim

1 . A method of utilizing a copolymer containing polyether blocks and polyamide blocks for manufacturing an inflatable catheter element, with improved bursting strength, in which said copolymer has the following characteristics:
number-average molecular mass of the PE blocks greater than 500 g/mol, number-average molecular mass of the PA blocks greater than 10 000 g/mol.

2 . The method as claimed in claim 1 , in which said PE blocks represent 1% to 10% by weight, relative to the total weight of the copolymer, and said PA blocks represent 80% to 99% by weight, relative to the total weight of the copolymer.

3 . The use method as claimed in claim 1 , in which the Shore D hardness (ISO 868) of the copolymer is greater than or equal to 72.

4 . The method as claimed in claim 1 , in which the flexural modulus of elasticity (ISO 178) of the copolymer is greater than 525 MPa.

5 . The method as claimed in claim 1 , in which the number-average molecular mass of the PE blocks is greater than 600 g/mol.

6 . The method as claimed in claim 1 , in which the number-average molecular mass of the PA blocks is within the range from 12 000 to 32 000 g/mol.

7 . The method as claimed in claim 1 , in which the PA blocks are formed from at least one monomer chosen from: 6, 11, 12, 4.6, 4.12, 4.14, 4.18, 6.6, 6.10, 6.12, 6.14, 6.18, Pip.10, 9.6, 9.12, 10.10, 10.12, 10.14, 10.18, 10.36, 10.T, 6.T, 9.T, MXD.6, MXD.10, B.10, B.12, B.14, B.18, B.36, P.10, P.12, P.14, P.18, P.36, random and/or block copolymers thereof, and mixtures thereof.

8 . The method as claimed in claim 1 , in which said at least one PE block comprises at least one polyether chosen from polyalkylene ether polyols, PPG, PO3G, PTMG, polyethers containing polyoxyalkylene sequences bearing NH2 chain ends, random and/or block copolymers thereof, and mixtures thereof.

9 . The method as claimed in claim 1 , in which the copolymer comprises polyether blocks composed predominantly on the basis of PTMG.

10 . A polyamide-based thermoplastic polymer composition, said composition comprising:
from 30% to 100% by weight of a copolymer containing polyether blocks and polyamide blocks for manufacturing an inflatable catheter element, with improved bursting strength, in which said copolymer has the following characteristics:
number-average molecular mass of the PE blocks greater than 500 g/mol,
number-average molecular mass of the PA blocks greater than 10 000 g/mol,
from 0 to 70% by weight of at least one other polymer chosen from polyamides, TPU, PVC, ABS, PS, PET, PETE, PVDF, ETFE, Polyimide, PEEK, PEKK, and silicone, from 0 to 40% of additive, relative to the total weight of the composition.

11 . The composition as claimed in claim 10 , in which the additive is chosen from tracers, antimicrobial or bactericidal agents or laser markers, coloring agents, especially pigments, dyes, pigments with an effect, UV stabilizers, antiaging agents, antioxidants; fluidizers, antiabrasion agents, mold-release agents, stabilizers; plasticizers, impact modifiers; surfactants; optical brighteners; fillers, silica, carbon black, carbon nanotubes, expanded graphite, titanium oxide or glass beads; fibers; waxes; and mixtures thereof.

12 . A granule or powder comprising a composition as defined in claim 10 .

13 . A method comprising manufacturing an inflatable catheter balloon with improved bursting strength with the granules as defined in claim 12 .

14 . A process for manufacturing a burst-proof catheter balloon, said process comprising:
a step of providing a copolymer containing polyether blocks and polyamide blocks for manufacturing an inflatable catheter element, with improved bursting strength, in which said copolymer has the following characteristics:
number-average molecular mass of the PE blocks greater than 500 g/mol,
number-average molecular mass of the PA blocks greater than 10 000 g/mol;
an optional step of mixing said copolymer with at least one other polymer and/or at least one additive, so as to manufacture a composition as defined in claim 10 ; a step of implementing said copolymer or said composition at a temperature TO within the range from 200 to 300° C.; a step of forming the balloon at a temperature below the Tm (melting point) of the copolymer; a step of recovering the balloon.

15 . The process as claimed in claim 14 , comprising at least one of the following steps: “dry blending”, extrusion, especially coextrusion, tube extrusion, overmolding, blow-molding, and mixtures thereof.

16 . (canceled)

17 . A burst-proof inflatable catheter element, wherein the composition of the element is in accordance with claim 10 .

18 . The balloon as claimed in claim 17 , comprising a wall thickness within the range of 1 to 250 μm.

19 . A catheter comprising a balloon in accordance with claim 17 .

Assignees

• Arkema France

Inventors

• Eustache René-Paul
• Malet Frédéric
• Gamache Eric
• Reyna-Valencia Alejandra
• Rauline Damien

Classifications

• A61M2025/1084

  having features for increasing the shape stability, the reproducibility or for limiting expansion, e.g. containments, wrapped around fibres, yarns or strands · CPC title

• C08G69/40 Primary

  Polyamides containing oxygen in the form of ether groups (C08G69/12, C08G69/32 take precedence) · CPC title

• A61L29/06 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61M25/10

  Balloon catheters ({A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02;} inflatable balloons for placing stents or stent-grafts A61F2/958 {; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00}) · CPC title

• C08L2205/035

  containing four or more polymers in a blend · CPC title