Joining and/or sealing tissues through photo-activated cross-linking of matrix proteins

Patent metadata

Field	Value
Publication number	US-2017232139-A1
Application number	US-201715494622-A
Country	US
Kind code	A1
Filing date	Apr 24, 2017
Priority date	Feb 14, 2006
Publication date	Aug 17, 2017
Grant date	—

Abstract

A method of joining and/or sealing tissues in a surgical procedure or medical treatment, comprising the steps of: (1) applying a matrix protein, a photoactivatable metal-ligand complex and an electron acceptor to a tissue portion; (2) irradiating said tissue portion to photoactivate the photoactivatable metal-ligand complex; thereby initiating a cross-linking reaction of the matrix protein to seal said tissue portion or join said tissue portion to an adjacent tissue portion.

First claim

1 - 20 . (canceled)

21 . A closure for a bleeding wound comprising:
a substrate suitable for application to a wound to stem bleeding; and a tissue adhesive carried by said substrate, said tissue adhesive comprising a matrix protein, a photoactivatable metal-ligand complex, and an electron acceptor, wherein said tissue adhesive is present in an amount effective to cause cross-linking reactions between one or more matrix proteins within or coating the closure and surrounding tissue of a patient upon implantation and irradiation.

22 . The closure of claim 21 wherein the matrix protein is selected from the group consisting of fibrinogen, fibrin, collagen, fibronectin, keratin, and laminin, or admixtures thereof.

23 . The closure of claim 21 wherein the photoactivatable metal-ligand is an Ru(II)/Pd(II), Cu(II), Ni(II), Mn(II), or Fe(III) complex.

24 . The closure of claim 23 wherein the complex is an Ru(II) bipyridyl complex, a Pd(II) porphyrin complex, a sulfonatophenyl Mn(II) complex, or a Fe(III) protoporphyrin complex.

25 . The closure of claim 24 wherein the complex is a tris (bipyridyl) Ru(II) complex.

26 . The closure of claim 25 wherein the complex is tris (bipyridyl) Ru(II) dichloride.

27 . The closure of claim 21 wherein the electron acceptor is a persulfate, periodate, perbromate, or a perchlorate compound.

28 . The closure of claim 27 wherein the electron acceptor is a persulfate compound.

29 . The closure of claim 28 wherein the electron acceptor is ammonium persulfate or sodium persulfate.

30 . The closure of claim 21 further comprising a drug or other therapeutic agent.

31 . The closure of claim 21 wherein the substrate is a collagen sheet, bandage, gauze, cloth, tampon, membrane, or sponge.

32 . The closure of claim 21 , wherein said tissue adhesive is coated on an outer surface of said substrate.

33 . A light activated tissue adhesive comprising:
a matrix protein selected from the group consisting of fibrinogen, fibrin, collagen, fibronectin, keratin and laminin, or admixtures thereof; a photoactivatable metal-ligand complex selected to absorb light in the visible region, said photoactivatable metal-ligand comprising a Ru(II), Pd(II), Cu(II), Ni(II), Mn(II), or Fe(III) complex; and an electron acceptor.

34 . The light activated tissue adhesive of claim 33 wherein the complex is an Ru(II) bipyridyl complex, a Pd(II) porphyrin complex, a sulfonatophenyl Mn(II) complex, or a Fe(III) protoporphyrin complex.

Assignees

• Cook Medical Technologies Llc

Inventors

• Brownlee Alan George
• Elvin Christopher Malcolm

Classifications

• C09J189/00

  Adhesives based on proteins; Adhesives based on derivatives thereof · CPC title

• A61L24/106 Primary

  Fibrin; Fibrinogen · CPC title

• A61L24/0015

  Medicaments; Biocides · CPC title

• A61L2400/04

  Materials for stopping bleeding · CPC title

• A61L24/02

  containing inorganic materials · CPC title