Nasal delivery

Patent metadata

Field	Value
Publication number	US-2017216540-A1
Application number	US-201615263630-A
Country	US
Kind code	A1
Filing date	Sep 13, 2016
Priority date	Nov 15, 2000
Publication date	Aug 3, 2017
Grant date	—

Abstract

A nasal delivery device for and a method of delivering a substance to a nasal cavity of a subject, the delivery device comprising: a delivery unit for delivering a flow entraining a substance to one nostril of a subject, the delivery unit including a nosepiece for fitting to a nostril of the subject; and a flow resistor unit for fitting to the other nostril of the subject, the flow resistor unit including a progressive resistor for progressively providing an increasing flow resistance to the delivered flow.

First claim

1 - 17 . (canceled)

18 . A nasal delivery device comprising:
a housing; a nosepiece for fitting in a nostril of a subject, the nosepiece connected to the housing; a substance supply unit configured to deliver a metered dose of a substance through the nosepiece; a flow resistor; and a trigger mechanism configured to actuate the substance supply unit upon generation of a predetermined pressure, the trigger mechanism comprising a flexible member defining a chamber within the housing in fluid communication with the nosepiece.

19 . The nasal delivery device of claim 18 , wherein the flexible member is a resilient membrane.

20 . The nasal delivery device of claim 18 , wherein the substance supply unit further comprises a biasing element and a release mechanism.

21 . The nasal delivery device of claim 20 , wherein the trigger mechanism further comprises a linkage coupling the flexible member and the release mechanism.

22 . The nasal delivery device of claim 18 , further comprising a nozzle, wherein the nozzle is fluidly connected to the substance supply unit and is configured to provide an aerosol spray through the nosepiece.

23 . The nasal delivery device of claim 18 , wherein the substance supply unit comprises a mechanical delivery pump.

24 . The nasal delivery device of claim 18 , wherein the substance is a liquid or a powder.

25 . The nasal delivery device of claim 18 , wherein the substance supply unit comprises a nebulizer.

26 . A nasal delivery device comprising:
a housing; a nosepiece for fitting in a nostril of a subject, the nosepiece connected to the housing; a substance supply unit configured to deliver a metered dose of a substance through the nosepiece; a mouthpiece through which the subject exhales to actuate the substance supply unit, the mouthpiece fluidly connected to the housing; a flow resistor; and a trigger mechanism configured to actuate the substance supply unit upon generation of a predetermined pressure, the trigger mechanism comprising a flexible member defining a chamber within the housing in fluid communication with the nosepiece.

27 . The nasal delivery device of claim 26 , wherein the mouthpiece is in fluid communication with the chamber.

28 . The nasal delivery device of claim 26 , wherein the flexible member is a resilient membrane.

29 . The nasal delivery device of claim 26 , wherein the substance supply unit further comprises a biasing element and a release mechanism.

30 . The nasal delivery device of claim 29 , wherein the trigger mechanism further comprises a linkage coupling the flexible member and the release mechanism.

31 . The nasal delivery device of claim 26 , wherein the substance is a liquid or a powder.

32 . A nasal delivery device comprising:
a housing; a first nosepiece for fitting in a nostril of a subject, the first nosepiece connected to the housing; a substance supply unit configured to deliver a metered dose of a substance through the first nosepiece; a mouthpiece through which the subject exhales to actuate the substance supply unit, the mouthpiece fluidly connected to the housing; a flow resistor, comprising a progressive flow resistor in fluid communication with a second nosepiece; and a trigger mechanism configured to actuate the substance supply unit upon generation of a predetermined pressure, the trigger mechanism comprising a flexible member defining a chamber within the housing in fluid communication with the first nosepiece.

33 . The nasal delivery device of claim 32 , wherein the progressive flow resistor, when inflated, indicates operation of the nasal delivery device.

34 . The nasal delivery device of claim 32 , wherein the flexible member is a resilient membrane.

35 . The nasal delivery device of claim 32 , wherein the substance supply unit further comprises a biasing element and a release mechanism.

36 . The nasal delivery device of claim 35 , wherein the trigger mechanism further comprises a linkage coupling the flexible member and the release mechanism.

37 . The nasal delivery device of claim 32 , wherein the substance is a liquid or a powder.

Assignees

• Optinose As

Inventors

• Djupesland Per Gisle

Classifications

• A61M15/002

  with air flow regulating means · CPC title

• A61M11/006

  operated by applying mechanical pressure to the liquid to be sprayed or atomised · CPC title

• A61M15/0098

  Activated by exhalation · CPC title

• A61M15/08 Primary

  Inhaling devices inserted into the nose · CPC title

• A61M15/0065

  Inhalators with dosage or measuring devices (A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52) · CPC title