Hydrogel

Patent metadata

Field	Value
Publication number	US-2017190844-A1
Application number	US-201615389918-A
Country	US
Kind code	A1
Filing date	Dec 23, 2016
Priority date	Jan 6, 2016
Publication date	Jul 6, 2017
Grant date	—

Abstract

A novel mussel-inspired injectable hydrogel with self-healing and anti-biofouling capabilities is developed, possessing great potential as drug delivery carrier. The hydrogel can heal autonomously from repeated structural damage and also effectively prevent nonspecific cell attachment and biofilm formation.

First claim

1 . A polymer comprising at least one block A and one block B, where A is a thermo-responsive copolymer comprising at least one monomer having a lower critical solution temperature and at least one self-healing monomer and B is a hydrophilic polymer block.

2 . The polymer of claim 1 in which A is formed of a random copolymer.

3 . The polymer of claim 2 in which the random copolymer comprises DN where D is dopamine acrylamide and N is NIPAM.

4 . The polymer of claim 3 having the structure:

5 . The polymer of claim 1 in which the self-healing monomer is provided with a self-healing property at least in part by catechol groups.

6 . The polymer of claim 5 in which A is formed of a random copolymer.

7 . The polymer of claim 6 in which the random copolymer comprises DN where D is dopamine acrylamide and N is NIPAM.

8 . The polymer of claim 7 having the structure:

9 . The polymer of claim 5 in which the self-healing monomer is provided with a self-healing property at least in part by aromatic groups.

10 . The polymer of claim 9 in which A is formed of a random copolymer.

11 . The polymer of claim 10 in which the random copolymer comprises DN where D is dopamine acrylamide and N is NIPAM.

12 . The polymer of claim 11 having the structure:

Assignees

• Univ Alberta

Inventors

• Zeng Hongbo
• Li Lin
• Yan Bin

Classifications

• C08G81/025 Primary

  containing polyether sequences · CPC title

• A61K9/06

  Ointments; Bases therefor; {Other semi-solid forms, e.g. creams, sticks, gels (composition of ointments, creams or gels A61K47/00)} · CPC title

• A61K47/34

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers (A61K47/10 takes precedence) · CPC title

• C08J3/075

  Macromolecular gels · CPC title

• C08J2387/00

  Characterised by the use of unspecified macromolecular compounds, obtained otherwise than by polymerisation reactions only involving unsaturated carbon-to-carbon bonds · CPC title