Microneedle patch and production method therefor

Patent metadata

Field	Value
Publication number	US-2017189661-A1
Application number	US-201515314700-A
Country	US
Kind code	A1
Filing date	Jun 1, 2015
Priority date	Jun 2, 2014
Publication date	Jul 6, 2017
Grant date	—

Abstract

Provided are a micro-needle patch and a manufacturing method thereof. The micro-needle patch includes: a support on one surface of which grooves are formed; a gel membrane for delivery of a transmitter to be transferred in which the grooves are filled with a mixture of the transmitter with a biodradable resin, the mixture being in a gel phase; a plurality of micro-needles projected on the other surface of the support and for penetrating the skin; a first protective film that covers the gel membrane and is adhered on the support; and a second protective film that covers the plurality of micro-needles and is adhered on the other surface, wherein passages are formed by being penetrated from the support to each of the plurality of micro-needles or formed by penetrating the support between the plurality of micro-needles, so that the transmitter of the gel membrane is transferred to the skin.

First claim

1 . A micro-needle patch comprising:
a support on one surface of which grooves are formed; a gel membrane for delivery of a transmitter to be transferred in which the grooves are filled with a mixture of the transmitter with a biodradable resin; a plurality of micro-needles projected on the other surface of the support and for penetrating the skin; a first protective film that covers the gel membrane and is adhered on the support; and a second protective film that covers the plurality of micro-needles and is adhered on the other surface of the support, wherein passages are formed by being penetrated from the support to each of the plurality of micro-needles or formed by penetrating the support between the plurality of micro-needles, so that the transmitter of the gel membrane is transferred to the skin.

2 . The micro-needle patch according to claim 1 , wherein the passages formed by being penetrated from the support to each of the plurality of micro-needles are formed by penetrating the respective centers of the support and the plurality of micro-needles or penetrating the respective side walls of the support and the plurality of micro-needles.

3 . The micro-needle patch according to claim 1 , wherein the gel membrane is formed in a gel phase in which the groove is filled with nanofibers made of a mixture of a drug or a skin cosmetic treatment fluid with the biodradable resin by using an electrospinning method.

4 . The micro-needle patch according to claim 1 , wherein the gel membrane is formed in a gel phase in which the groove is filled with droplets made of a mixture of a drug or a skin cosmetic treatment fluid with the biodradable resin by using an electrospinning method.

5 . The micro-needle patch according to claim 1 , wherein a material of the support is polyetherimide such as ULTEM®.

6 . The micro-needle patch according to claim 1 , wherein the support is formed integrally with the plurality of micro-needles, and the support is formed of a material that is biodegradable or soluble by a human body fluid.

7 . The micro-needle patch according to claim 6 , wherein the material that is biodegradable or soluble comprises one of polyethylene glycol (PEG), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), cellulose, hydroxypropyl cellulose (HPC), hydroxyethyl cellulose (HEC), hydroxypropylmethylcellulose (HPMC).

8 . The micro-needle patch according to claim 1 , wherein the micro-needle is configured so that width of an upper region of the micro-needle is narrower than that of a lower region relative to the surface of the support.

9 . The micro-needle patch according to claim 1 , wherein height of the micro-needle is less than 1000 μm.

10 . The micro-needle patch according to claim 1 , wherein the transmitter comprises a drug, in which the drug is a single drug or a mixed drug of anesthetics, narcotic vaccines, adjuvants, immunogens, immunomodulators, immune reagents, immune stimulants, analgesics, antibiotics, chitosans, collagens, gelatins, hyaluronic acids, polylactic acids, and polyglycolic acids.

11 . The micro-needle patch according to claim 1 , wherein the transmitter comprises a skin cosmetic treatment fluid, in which the skin cosmetic treatment fluid is made of cosmetic ingredients for skin care.

12 . A method of manufacturing a micro-needle patch, the method comprising the steps of:
preparing a support on one surface of which a groove is formed and on the other surface of which a plurality of micro-needles are projected, and that covers the plurality of micro-needles, in which a needle protective film is adhered on the other surface of the support; preparing a spinning solution or a spraying solution by mixing a transmitter to be transferred, a biodradable resin, and a solvent; forming a gel membrane for delivery of the transmitter to be transferred, by electrospinning the spinning solution or electrospraying the spraying solution into the groove of the support; and adhering a protective film for protecting the gel membrane on the support.

13 . The method of claim 12 , wherein the forming a gel membrane for delivery of the transmitter to be transferred, comprises the steps of:
inserting a plurality of the supports into a plurality of seating portions formed in a tray; and forming a gel membrane for delivery of the transmitter to be transferred, by electrospinning the spinning solution or electrospraying the spraying solution into the grooves of the plurality of the supports.

14 . The method of claim 13 , wherein the plurality of the supports differ from the plurality of the seating portions in size.

15 . The method of claim 12 , wherein the forming a gel membrane for delivery of the transmitter to be transferred, comprises the step of: forming the gel membrane in a gel phase in which the groove is filled with nanofibers made of a mixture of the transmitter with the biodradable resin by electrospinning the spinning solution.

16 . The method of claim 12 , wherein the forming a gel membrane for delivery of the transmitter to be transferred, comprises the steps of: forming the gel membrane in a gel phase in which the groove is filled with droplets made of a mixture of the transmitter with the biodradable resin by electrospinning the spinning solution.

Assignees

• Amolifescience Co Ltd

Inventors

• Lee Jae Yeong

Classifications

• A61K9/0021

  Intradermal administration, e.g. through microneedle arrays or needleless injectors · CPC title

• A61K47/32

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers {, poly(meth)acrylates, or polyvinyl pyrrolidone} · CPC title

• A45D34/04

  Appliances specially adapted for applying liquid, e.g. using roller or ball · CPC title

• A61K9/7007

  Drug-containing films, membranes or sheets (A61K9/0041, A61K9/0043, A61K9/006, A61K9/0063 take precedence) · CPC title

• A61M37/0015 Primary

  by using microneedles · CPC title