Method for the preparation of a cell culture insert with at least one membrane
US-12162212-B2 · Dec 10, 2024 · US
US2017182560A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2017182560-A1 |
| Application number | US-201615382574-A |
| Country | US |
| Kind code | A1 |
| Filing date | Dec 16, 2016 |
| Priority date | Dec 16, 2015 |
| Publication date | Jun 29, 2017 |
| Grant date | — |
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A printer fabricates an object from a computerized model using a fused filament fabrication process and a bulk metallic glass build material. By heating the bulk metallic glass at an elevated temperature in between an object and adjacent support structures, an interface layer can be interposed between the object and support where the bulk metallic glass becomes crystallized to create a more brittle interface that facilitates removal of the support structure from the object after fabrication.
Opening claim text (preview).
What is claimed is: 1 . A method for fabricating an interface between a support structure and an object using a bulk metallic glass, the method comprising: fabricating a layer of a support structure for an object from a bulk metallic glass having a super-cooled liquid region at a first temperature above a glass transition temperature for the bulk metallic glass; fabricating an interface layer of the bulk metallic glass on the layer of the support structure at a second temperature sufficiently high to promote crystallization of the bulk metallic glass during fabrication; and fabricating a layer of the object on the interface layer at a third temperature below the second temperature and above the glass transition temperature and below the second temperature. 2 . The method of claim 1 further comprising removing the support structure from the object by fracturing the support structure at the interface layer between the support structure and the object where the bulk metallic glass is crystallized. 3 . The method of claim 1 further comprising heating the object and the support structure after fabrication to substantially fully crystallize the interface layer. 4 . The method of claim 1 wherein fabricating the layer of the support structure includes fabricating the layer of the support structure with a fused filament fabrication process. 5 . The method of claim 1 wherein fabricating the layer of the object include fabricating the layer of the object with a fused filament fabrication process. 6 . The method of claim 1 wherein fabricating the layer of the object includes fabricating the layer of the object with a laser sintering fabrication process and a powdered bulk metallic glass build material. 7 . The method of claim 1 wherein the crystallization of the bulk metallic glass yields a fracture toughness at the interface not exceeding twenty MPa√m. 8 . A computer program product for controlling a printer in a three-dimensional fabrication of a metallic object, the computer program product comprising computer executable code embodied in a non-transitory computer readable medium that, when executing on the printer, causes the printer to perform the steps of: fabricating a layer of a support structure for an object from a bulk metallic glass having a super-cooled liquid region at a first temperature above a glass transition temperature for the bulk metallic glass; fabricating an interface layer of the bulk metallic glass on the layer of the support structure at a second temperature sufficiently high to promote crystallization of the bulk metallic glass during fabrication; and fabricating a layer of the object on the interface layer at a third temperature below the second temperature and above the glass transition temperature and below the second temperature. 9 . The computer program product of claim 8 further comprising code that causes the printer to perform the step of heating the object and the support structure after fabrication to substantially fully crystallize the interface layer. 10 . The computer program product of claim 8 wherein fabricating the layer of the support structure includes fabricating the layer of the support structure with a fused filament fabrication process. 11 . The computer program product of claim 8 wherein fabricating the layer of the object include fabricating the layer of the object with a fused filament fabrication process. 12 . The computer program product of claim 8 wherein fabricating the layer of the object includes fabricating the layer of the object with a laser sintering fabrication process and a powdered bulk metallic glass build material. 13 . The computer program product of claim 8 wherein the crystallization of the bulk metallic glass yields a fracture toughness at the interface not exceeding twenty MPa√m. 14 . A printer for three-dimensional fabrication of metallic objects, the printer comprising: a nozzle configured to extrude a bulk metallic glass having a super-cooled liquid region at a first temperature above a glass transition temperature for the bulk metallic glass; a robotic system configured to move the nozzle in a fused filament fabrication process to fabricate a support structure and an object based on a computerized model; and a controller configured to fabricate an interface layer between the support structure and the object by depositing the bulk metallic glass in the interface layer at a second temperature greater than the first temperature, the second temperature sufficiently high to promote crystallization of the bulk metallic glass during fabrication. 15 . The printer of claim 14 wherein the second temperature is near a melting temperature for the bulk metallic glass. 16 . The printer of claim 14 wherein the second temperature is near a critical crystallization temperature for the bulk metallic glass. 17 . The printer of claim 14 further comprising a build plate, the robotic system configured to move the nozzle in a three-dimensional path relative to the build plate in order to fabricate the support structure and the object on the build plate. 18 . The printer of claim 17 further comprising a build chamber, the build chamber housing at least the build plate and the nozzle, the build chamber maintaining a build environment suitable for fabricating the object and the support structure on the build plate. 19 . The printer of claim 18 further comprising a heater for maintaining an elevated temperature within the build environment. 20 . The printer of claim 14 further comprising a cooling system configured to apply a cooling fluid to the bulk metallic glass as the bulk metallic glass exits the nozzle.
Thermoplastic materials · CPC title
temperature, temperature profile · CPC title
Processes of additive manufacturing · CPC title
for controlling or regulating additive manufacturing processes · CPC title
Use of metals, their alloys or their compounds, as filler · CPC title
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