Method for the preparation of a cell culture insert with at least one membrane
US-12162212-B2 · Dec 10, 2024 · US
US2017173697A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2017173697-A1 |
| Application number | US-201615382558-A |
| Country | US |
| Kind code | A1 |
| Filing date | Dec 16, 2016 |
| Priority date | Dec 16, 2015 |
| Publication date | Jun 22, 2017 |
| Grant date | — |
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A printer fabricates an object from a computerized model using a fused filament fabrication process and a bulk metallic glass build material. By using thermally mismatched bulk metallic glasses for an object and adjacent support structures, the interface layer between these structures can be melted and crystallized to create a more brittle interface that facilitates removal of the support structure from the object after fabrication.
Opening claim text (preview).
What is claimed is: 1 . A method for controlling a printer in a three-dimensional fabrication of a metallic object, the method comprising: fabricating a support structure for an object from a first bulk metallic glass having a first super-cooled liquid region; and fabricating an object on the support structure from a second bulk metallic glass different than the first bulk metallic glass, wherein the second bulk metallic glass has a glass transition temperature sufficiently high to promote a crystallization of the first bulk metallic glass during fabrication, and wherein the second bulk metallic glass is deposited onto the support structure at a temperature at or above the glass transition temperature of the second bulk metallic glass to induce crystallization of the support structure at an interface between the support structure and the object. 2 . The method of claim 1 further comprising removing the support structure from the object by fracturing the support structure at the interface where the first bulk metallic glass is crystallized. 3 . The method of claim 1 wherein the second bulk metallic glass has a glass transition temperature above a critical crystallization temperature of the first bulk metallic glass. 4 . The method of claim 1 further comprising heating the second bulk metallic glass to a second temperature above a critical crystallization temperature of the first bulk metallic glass before deposition onto the first bulk metallic glass. 5 . The method of claim 1 wherein fabricating the support structure includes fabricating a base of the support structure from a first material, and an interface layer of the support structure between the base and the object from the first bulk metallic glass. 6 . The method of claim 1 wherein the crystallization of the first bulk metallic glass yields a fracture toughness at the interface not exceeding twenty MPa√m. 7 . A computer program product for controlling a printer in a three-dimensional fabrication of a metallic object, the computer program product comprising computer executable code embodied in a non-transitory computer readable medium that, when executing on the printer, causes the printer to perform the steps of: fabricating a support structure for an object from a first bulk metallic glass having a first super-cooled liquid region; and fabricating an object on the support structure from a second bulk metallic glass different than the first bulk metallic glass, wherein the second bulk metallic glass has a glass transition temperature sufficiently high to promote a crystallization of the first bulk metallic glass during fabrication, and wherein the second bulk metallic glass is deposited onto the support structure at a temperature at or above the glass transition temperature of the second bulk metallic glass to induce crystallization of the support structure at an interface between the support structure and the object. 8 . The computer program product of claim 7 further comprising code that causes the printer to perform the step of removing the support structure from the object by fracturing the support structure at the interface where the first bulk metallic glass is crystallized. 9 . The computer program product of claim 7 wherein the second bulk metallic glass has a glass transition temperature above a critical crystallization temperature of the first bulk metallic glass. 10 . The computer program product of claim 7 further comprising code that causes the printer to perform the step of heating the second bulk metallic glass to a second temperature above a critical crystallization temperature of the first bulk metallic glass before deposition onto the first bulk metallic glass. 11 . The computer program product of claim 7 wherein fabricating the support structure includes fabricating a base of the support structure from a first material, and an interface layer of the support structure between the base and the object from the first bulk metallic glass. 12 . The computer program product of claim 7 wherein the crystallization of the first bulk metallic glass yields a fracture toughness at the interface not exceeding twenty MPa√m. 13 . A printer for three-dimensional fabrication of metallic objects, the printer comprising: a first nozzle configured to extrude a first bulk metallic glass having a first super-cooled liquid region; a second nozzle configured to extrude a second bulk metallic glass different from the first bulk metallic glass, the second bulk metallic glass having a glass transition temperature sufficiently high to promote a crystallization of the first bulk metallic glass during when extruded adjacent to the first bulk metallic glass; a robotic system configured to move the first nozzle and the second nozzle in a fused filament fabrication process to fabricate a support structure and an object based on a computerized model; and a controller configured to fabricate the support structure using the first bulk metallic glass from the first nozzle and to fabricate the object on the support structure from the second bulk metallic glass, wherein the controller is configured to deposit the second bulk metallic glass onto the support structure at a temperature at or above the glass transition temperature of the second bulk metallic glass to induce crystallization of the support structure at an interface between the support structure and the object. 14 . The printer of claim 13 further comprising a build plate, the robotic system configured to move the first nozzle and the second nozzle in a three-dimensional path relative to the build plate in order to fabricate the support structure and the object on the build plate. 15 . The printer of claim 14 further comprising a build chamber, the build chamber housing at least the build plate, the first nozzle and the second nozzle, and the build chamber maintaining a build environment suitable for fabricating the object and the support structure on the build plate. 16 . The printer of claim 15 further comprising a heater for maintaining an elevated temperature within the build environment. 17 . The printer of claim 16 wherein the heater includes an induction heating system. 18 . The printer of claim 16 wherein the heater includes a resistive heating system. 19 . The printer of claim 13 further comprising a cooling system configured to apply a cooling fluid to the second bulk metallic glass as the second bulk metallic glass exits the second nozzle. 20 . The printer of claim 13 wherein the second bulk metallic glass has a glass transition temperature above a critical crystallization temperature of the first bulk metallic glass.
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