Porous articles for separation

Patent metadata

Field	Value
Publication number	US-2017157591-A1
Application number	US-201415039664-A
Country	US
Kind code	A1
Filing date	Dec 16, 2014
Priority date	Dec 18, 2013
Publication date	Jun 8, 2017
Grant date	—

Abstract

Porous articles are provided that include a fibrous porous matrix and porous polymeric particles. The porous polymeric particles are distributed throughout the fibrous porous polymeric matrix. The porous article can be used to prepare a separation device or a system that includes the separation device. The porous articles can be used for the separation of a target material such as a microorganism (i.e., cellular analyte) from a sample.

First claim

1 . A porous article comprising:
a) porous polymeric particles, wherein the porous polymeric particles comprise a polymerized product of a reaction mixture comprising
i) a monomer composition comprising at least 10 weight percent of a first monomer of Formula (I)
CH 2 ═C(R 1 )—(CO)—O[—CH 2 —CH 2 —O] p —(CO)—C(R 1 )═CH 2   (I)

based on a total weight of the monomer composition, wherein p is an integer equal to at least 1 and R 1 is hydrogen or alkyl; and
ii) a poly(propylene glycol) having a weight average molecular weight of at least 500 grams/mole,
wherein the poly(propylene glycol) is removed from the polymerized product to provide the porous polymeric particles; and b) a fibrous porous matrix comprising a mixture of hydrophobic and hydrophilic polymeric fibers, wherein the porous polymeric particles are distributed throughout the fibrous porous matrix.

2 . The porous article of claim 1 , wherein the fibrous porous matrix comprises nonwoven fibers.

3 . The porous article of claim 1 , wherein the reaction mixture comprises
1) a first phase having a first volume and comprising
i) a compound of Formula (II)
HO(—CH 2 CH(OH)CH 2 O) n   (II)

wherein n is an integer equal to at least 1; and
ii) a nonionic surfactant;
2) a second phase having a second volume and being dispersed in the first phase, wherein the first volume is greater than the second volume and wherein the second phase comprises
i) the monomer composition comprising at least 10 weight percent of the monomer of Formula (I) based on the total weight of the monomer composition; and
ii) the poly(propylene glycol) having a weight average molecular weight of at least 500 grams/mole
wherein the poly(propylene glycol) is removed from the polymerized product to provide the porous polymeric particle.

4 . The porous article of claim 1 , wherein the monomer composition further comprises a second monomer having one (meth)acryloyl group.

5 . The porous article of claim 1 , wherein the monomer composition further comprises a second monomer of Formula (III) of Formula (IV)
CH 2 ═CR 1 —(CO)—O—Y—R 2   (III)
CH 2 ═CR 1 —(CO)—O—R 3   (IV)
wherein
R 1 is hydrogen or methyl;
Y is a single bond, alkylene, oxyalkylene, or poly(oxyalkylene);
R 2 is a carbocyclic group or heterocyclic group; and
R 3 is a linear or branched alkyl.

6 . The porous article of claim 1 , wherein the fibrous porous matrix comprises polymeric fibers selected from polyamides, polyolefins, and polysulfones.

7 . The porous article of claim 1 , wherein the porous article comprises 10 to 55 weight percent porous polymeric particles based on a total dried weight of the porous article and 45 to 90 weight percent fibrous porous matrix based on the total dried weight of the porous article.

8 . The porous article of claim 1 , wherein the fibrous porous matrix is a nonwoven fibrous layer and further comprises inorganic fibers.

9 . A method of making a porous article, the method comprising:
a) providing a plurality of porous polymeric particles, wherein the porous polymeric particles comprise a polymerized product of a reaction mixture comprising
i) a monomer composition comprising at least 10 weight percent of a monomer of Formula (I)
CH 2 ═C(R 1 )—(CO)—O[—CH 2 —CH 2 —O] p —(CO)—C(R 1 )═CH 2   (I)

based on a total weight of the monomer composition, wherein p is an integer equal to at least 1 and R 1 is hydrogen or alkyl; and
ii) a poly(propylene glycol) having a weight average molecular weight of at least 500 grams/mole,
wherein the poly(propylene glycol) is removed from the polymerized product to provide the porous polymeric particles; and b) distributing the porous polymeric particle throughout a fibrous porous matrix comprising a mixture of hydrophobic and hydrophilic polymeric fibers.

10 . The method of claim 9 , wherein the reaction mixture comprises
1) a first phase having a first volume and comprising
i) a compound of Formula (II)
HO(—CH 2 CH(OH)CH 2 O) n   (II)

wherein n is an integer equal to at least 1; and
ii) a nonionic surfactant;
2) a second phase having a second volume and being dispersed in the first phase, wherein the first volume is greater than the second volume and wherein the second phase comprises
i) a monomer composition comprising at least 10 weight percent of the monomer of Formula (I); and
ii) the poly(propylene glycol) having a weight average molecular weight of at least 500 grams/mole,
wherein the poly(propylene glycol) is removed from the polymerized product to provide the porous polymeric particle.

11 . The method of claim 9 , wherein the porous article comprises 10 to 55 weight percent porous polymeric particles based on a total dried weight of the porous article and 45 to 90 weight percent fibrous porous matrix based on the total dried weight of the porous article.

12 . A separation device comprising:
a) a container having an inlet and an outlet for passage of a fluid stream through the container; and b) a porous article of claim 1 positioned within the container.

13 . A system comprising:
a) a separation device comprising
i) a container having an inlet and an outlet; and
ii) a porous article of claim 1 positioned within the container; and
b) a fluid stream passing through the separation device, wherein the fluid stream enters the inlet and exits the outlet of the container and contacts the porous article positioned within the container.

14 . The system of claim 13 , wherein the fluid stream comprises a target material and wherein the porous article removes the target material from the fluid stream.

15 . The system of claim 14 , wherein the target material comprises a microorganism.

16 . A method of separating a target material, the method comprising:
a) providing a separation device comprising
i) a container having an inlet and an outlet; and
ii) a porous article of claim 1 positioned within the container; and
b) passing a fluid stream comprising a target material through the separation device, wherein the fluid stream enters the inlet and exits the outlet of the container and contacts the porous article positioned within the container; c) removing the target material from the fluid stream, wherein the target material is bound or captured by the porous article.

17 . The method of claim 16 , wherein the target material comprises a microorganism.

18 . The method of claim 16 , wherein the microorganism is viable after being bound or captured by the porous article.

19 . The method of claim 16 , further comprising detecting the amount of microorganism bound or captured by the porous article.

20 . The method of claim 16 , wherein removing the target material purifies the fluid stream.

Assignees

• 3M Innovative Properties Co

Inventors

• Kshirsagar Manjiri T
• Sahouani Hassan

Classifications

• C08J2333/06

  of esters containing only carbon, hydrogen, and oxygen, the oxygen atom being present only as part of the carboxyl radical · CPC title

• C08J9/286

  the liquid phase being a solvent for the monomers but not for the resulting macromolecular composition, i.e. macroporous or macroreticular polymers · CPC title

• B01J20/3064

  Addition of pore forming agents, e.g. pore inducing or porogenic agents · CPC title

• B01J20/261 Primary

  obtained by reactions only involving carbon to carbon unsaturated bonds (macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds per se C08F) · CPC title

• C08F220/12

  of monohydric alcohols or phenols · CPC title