Bone matrix compositions having nanoscale textured surfaces

Patent metadata

Field	Value
Publication number	US-2017136149-A1
Application number	US-201715418351-A
Country	US
Kind code	A1
Filing date	Jan 27, 2017
Priority date	Jun 15, 2007
Publication date	May 18, 2017
Grant date	—

Abstract

Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.

First claim

1 .- 17 . (canceled)

18 . A method for producing a demineralized bone matrix composition comprising: providing bone; demineralizing the bone; drying the bone such that collagen fibrils on a surface of the bone are compromised; and adding nanostructures to the bone to provide a nanoscale textured surface.

19 . The method of claim 18 , wherein adding nanostructures to the bone comprises a coating/precipitation process.

20 . The method of claim 18 , wherein adding nanostructures to the bone comprises a phase separation process.

21 . The method of claim 18 , wherein adding nanostructures to the bone comprises an electro spinning process.

22 . The method of claim 18 , wherein adding nanostructures to the bone comprises adding collagen to the bone.

23 . The method of claim 18 , wherein adding nanostructures materials to the bone comprises adding polylactide nanofibers to the bone.

24 . The method of claim 18 , wherein adding nanostructures to the bone comprises adding collagen, polylactide, polycaprolactone, polyglycolide, chitosan, gelatin, or other nanofibrous material to the bone.

25 . The method of claim 18 , wherein the nanofibrous materials include an encapsulated biological active molecule.

26 . The method of claim 18 , further comprising adding extract to the bone.

Assignees

• Warsaw Orthopedic Inc

Inventors

• Wei Guobao
• Behnam Keyvan
• Forsyth Nanette

Classifications

• A61F2/28

  Bones · CPC title

• A61F2002/4646

  Devices for cleaning bone graft · CPC title

• A61F2/3094

  Designing or manufacturing processes · CPC title

• A61L2300/62

  Encapsulated active agents, e.g. emulsified droplets · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title