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Polymer, thermosensitive carrier and use thereof
US2017119676A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2017119676-A1 |
| Application number | US-201615268933-A |
| Country | US |
| Kind code | A1 |
| Filing date | Sep 19, 2016 |
| Priority date | Oct 30, 2015 |
| Publication date | May 4, 2017 |
| Grant date | — |
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- Title
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Abstract
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Disclosed herein are a novel polymer, a thermosensitive carrier prepared using the same and use thereof. The novel polymer is essentially composed of a PEO-PPO-PEO block copolymer and silane.
First claim
Opening claim text (preview).
What is claimed is: 1 . An organic/inorganic amphilic thermosensitive polymer, having a structure as shown in Formula (1): 2 . A method for preparing the polymer according to claim 1 , comprising: a) mixing a PEO-PPO-PEO block polymer with N-methyl-2-pyrrolidone, succinic anhydride, and 4-(dimethyl-amino)pyridine (DMAP), and reacting, to afford a PEO-PPO-PEO block polymer-carboxylate; and b) mixing the PEO-PPO-PEO block polymer-carboxylate with thionyl chloride, triethyl amine (TEA) and 3-aminopropyltriethoxysilicane (APTES), and reacting, to afford the compound of Formula (1). 3 . The method according to claim 2 , wherein the temperature is raised to 50° C. in Step a), and the reaction is carried out under a nitrogen atmosphere. 4 . The method according to claim 3 , wherein the temperature is raised to 60° C. in Step a). 5 . The method according to claim 3 , wherein the PEO-PPO-PEO block polymer is F127. 6 . A thermosensitive carrier, comprising: a nano gold; and an outer coating entrapping the nano gold, wherein the outer coating is comprised of the organic/inorganic amphilic thermosensitive polymer according to claim 1 . 7 . The thermosensitive carrier according to claim 6 , wherein the nano gold is gold nanorods. 8 . The thermosensitive carrier according to claim 6 , further comprising a pharmaceutical composition entrapped by the outer coating. 9 . The thermosensitive carrier according to claim 8 , wherein the pharmaceutical composition is an anti-cancer agent. 10 . Use of the thermosensitive carrier according to claim 8 in the preparation of drugs for treating cancers.
Assignees
Inventors
Classifications
Block or graft polymers not provided for in groups C09D101/00 - C09D185/04 · CPC title
containing silicon · CPC title
Disruption, e.g. by heat or ultrasounds, sonophysical or sonochemical activation, e.g. thermosensitive or heat-sensitive liposomes, disruption of calculi with a medicinal preparation and ultrasounds · CPC title
Thermosensitive paints · CPC title
Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy · CPC title
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Frequently asked questions
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- What does patent US2017119676A1 cover?
- Disclosed herein are a novel polymer, a thermosensitive carrier prepared using the same and use thereof. The novel polymer is essentially composed of a PEO-PPO-PEO block copolymer and silane.
- Who is the assignee on this patent?
- Inst Nuclear Energy Res Atomic Energy Council Executive Yuan Roc
- What technology area does this patent fall under?
- Primary CPC classification A61K31/337. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Thu May 04 2017 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).