Two-dimensional micro- and nano-pattern, methods for forming the same, and microfluidic devices formed therefrom

Patent metadata

Field	Value
Publication number	US-2017100716-A1
Application number	US-201615293134-A
Country	US
Kind code	A1
Filing date	Oct 13, 2016
Priority date	Oct 13, 2015
Publication date	Apr 13, 2017
Grant date	—

Abstract

Methods of forming two-dimensional nanopatterns are provided. The method may comprise periodically contacting a vibrating tool comprising a patterned grating edge with a substrate along a first direction in a grating-vibrational indentation patterning process. The patterned grating edge defines a plurality of rows and a plurality of interspersed troughs. The periodic contacting creates a two dimensional array of discontinuous voids in a single-stroke across the surface of the substrate. In other aspects, a microfluidic device for selective arrangement of a microspecies or nanospecies is provided, that includes a substrate comprising a surface defining a two-dimensional pattern of microvoids or nanovoids. In yet other aspects, the present disclosure provides a method for selective arrangement of a microspecies or nanospecies on a substrate.

First claim

What is claimed is:

1 . A method of forming a two-dimensional pattern on a substrate, the method comprising:
periodically contacting a vibrating tool comprising a patterned grating edge with a substrate along a first direction in a grating-vibrational indentation patterning process, wherein the patterned grating edge defines a plurality of rows and a plurality of interspersed troughs and the periodically contacting creates a two dimensional array of discontinuous voids in a single-stroke across the substrate.

2 . The method of claim 1 , wherein the vibrating tool is a cleaved hard mold tool comprising silicon dioxide (SiO 2 ).

3 . The method of claim 1 , wherein the plurality of rows defines a period of greater than or equal to about 50 nm to less than or equal to about 10 μm.

4 . The method of claim 1 , wherein the substrate is a polymeric substrate selected from the group consisting of: polyethylene terephthalate (PET), polycarbonate (PC), phenol formaldehyde resins (PF), and perfluoroalkoxy (PFA).

5 . A microfluidic device for selective arrangement of a microspecies and nanospecies, the device comprising:
a substrate comprising a surface defining a two-dimensional pattern of microvoids or nanovoids; a microfluidic compartment, wherein the substrate is disposed within the compartment and the surface contacts a fluid comprising the microspecies and nanospecies contained in the microfluidic compartment; an inlet to the microfluidic compartment; and an outlet to the microfluidic compartment; wherein the fluid comprising the microspecies and nanospecies is introduced to the microfluidic compartment via the inlet and exits the microfluidic compartment via the outlet.

6 . The microfluidic device of claim 5 , wherein the substrate is a polymeric substrate selected from the group consisting of: polyethylene terephthalate (PET), polycarbonate (PC), phenol formaldehyde resins (PF), and perfluoroalkoxy (PFA).

7 . The microfluidic device of claim 5 , wherein the microfluidic compartment comprises at least one transparent region through which the surface of the substrate is visible to an external detector.

8 . The microfluidic device of claim 5 , wherein the two-dimensional pattern of nanovoids is a sinusoidal pattern of nanovoids having a period of greater than or equal to about 50 nm to less than or equal to about 1 μm.

9 . The microfluidic device of claim 5 , wherein the two-dimensional pattern of microspecies and nanospecies is a sinusoidal pattern of nanovoids.

10 . The microfluidic device of claim 5 , wherein the surface has a first charge and the microspecies and nanospecies has a second charge opposite charge to the first charge, so that the surface attracts the microspecies and nanospecies.

11 . The microfluidic device of claim 5 , wherein the surface comprises a coating having a first charge and the microspecies and nanospecies has a second charge opposite charge to the first charge, so that the surface attracts the microspecies and nanospecies.

12 . The microfluidic device of claim 11 , wherein the coating comprises aluminum oxide (Al 2 O 3 ) having a positive charge and the microspecies and nanospecies has a negative charge.

13 . A method for selective arrangement of a microspecies and nanospecies on a substrate, the method comprising:
passing a fluid comprising a microspecies and nanospecies over a surface of the substrate comprising a two-dimensional pattern of microvoids or nanovoids, wherein the microspecies and nanospecies has a first charge and the surface has a second charge opposite to the first charge, wherein at least a portion of the microspecies and nanospecies in the fluid is trapped and assembled within the two-dimensional pattern of microvoids or nanovoids.

14 . The method of claim 13 , wherein the microspecies and nanospecies is a charged biological species or a charged nanoparticle.

15 . The method of claim 14 , wherein the charged biological species is selected from the group consisting of: proteins, peptides, nucleic acids, cells, viruses, bacteria, and combinations thereof.

16 . The method of claim 13 , wherein the two-dimensional pattern of microvoids or nanovoids are sinusoidal.

17 . The method of claim 13 , wherein each void of the two-dimensional pattern of microvoids or nanovoids has a shape selected from, pyramidal or hemispherical.

18 . The method of claim 13 , wherein the fluid is introduced into an inlet of a microfluidic compartment in which the substrate is disposed, so that the fluid flows over the surface of the substrate comprising a two-dimensional pattern of microvoids or nanovoids in the compartment, wherein after at least a portion of the microspecies and nanospecies in the fluid is trapped and assembled within the two-dimensional pattern of microvoids or nanovoids, the remaining fluid passes out an exit of the microfluidic compartment.

Assignees

• Univ Michigan Regents

Inventors

• Ok Jong G
• Guo Lingjie J
• Chen Long
• Panday Ashwin

Classifications

• B01L2300/0893

  having a very large number of wells, microfabricated wells · CPC title

• B01L3/502707 Primary

  characterised by the manufacture of the container or its components · CPC title

• B01L2300/0877

  Flow chambers · CPC title

• B01L2200/12

  Specific details about manufacturing devices · CPC title

• B81B2201/058

  Microfluidics not provided for in B81B2201/051 - B81B2201/054 · CPC title