Reactive Oxidative Species Generating Materials and Methods of Use

Patent metadata

Field	Value
Publication number	US-2017087250-A1
Application number	US-201615377022-A
Country	US
Kind code	A1
Filing date	Dec 13, 2016
Priority date	Aug 31, 2012
Publication date	Mar 30, 2017
Grant date	—

Abstract

Materials capable of delivering stabilized free radicals to targeted treatment sites. The materials comprise semi-crystalline, hydrolytically degradable polymers that are subjected to ionizing radiation to create stabilized free radicals therein. Upon exposure to oxygen containing aqueous media, the materials generate reactive oxidative species which are useful in biological processes,

First claim

1 .- 12 . (canceled)

13 . A method of making a biocompatible material with enhanced reactive oxidative species generation by
a. blending at least two hydrolytically degradable semi-crystalline polymeric materials to a blend; and b. subjecting said blend to ionizing radiation at a given radiation dose to create stabilized free radicals therein, wherein upon contacting the blend with an oxygen-containing aqueous media, multi-phasic generation of reactive oxidative species occurs, and wherein the quantity of the reactive oxidative species produced by the blend is greater than the weighted average of reactive oxidative species produced by the at least two individual hydrolytically degradable semi-crystalline polymeric materials having been subjected to ionizing radiation at the given radiation dose,

14 .- 21 . (canceled)

22 . The method of claim 13 . wherein an initial burst of reactive oxidative species production and a subsequent sustained period of reactive oxidative species production occurs upon contacting the blend with the oxygen-containing aqueous media.

23 . The method of claim 13 , wherein the at least two hydrolytically degradable semi-crystalline polymeric materials comprise a first polymeric material and a second polymeric material.

24 . The method of claim 23 , wherein the first polymeric material has a different hydrolytic degradation rate than the second polymeric material.

25 . The method of claim 23 , wherein the first polymeric material has a different degree of crystallinity than the second polymeric material.

26 . The method of claim 23 , wherein the first polymeric material and the second polymeric material have been subjected to different doses of ionizing radiation.

27 . The method of claim 23 , wherein the first and second polymeric materials each comprise stabilized free radicals.

28 . The method of claim 23 , wherein the first polymeric material comprises stabilized free radicals and the second polymeric materials does not contain stabilized free radicals.

29 . The method of claim 23 , wherein the first polymeric material comprises a different amount of stabilized free radicals than the second polymeric material.

30 . The method of claim 23 , wherein at least one of said first and second polymeric materials is bloabsorbable.

31 . The method of claim 30 , wherein the btoalesorbable polymer is selected from the group consisting of poly(dioxarione), poly(glycolide), poly(lactide) poly(ε-caprolactone), poly(anhydrides) such as poly(sebacic acid), poly(hydroxyalkanoates) such as poly(3-hydroxybutyrate), copolymers of any of these and combinations thereof.

32 . The method of claim 22 , wherein said subjecting comprises subjecting the blend to ionizing radiation at a dose rate less than about 50 kGy.

33 . The method of claim 22 , wherein said subjecting comprises subjecting the blend to ionizing radiation at a total dose from about 30 kGy to about 50 kGy.

34 . The method of claim 22 , wherein the blend further comprises at least one therapeutically active agent.

35 . The method of claim 22 , wherein the blend is sterilized by a non-ionizing radiation method.

36 . The method of claim 22 , wherein said subjecting the blend to ionizing radiation occurs in an inert atmosphere.

Assignees

• Gore & Ass

Inventors

• Brown Tiffany J
• Lafleur Adam S
• Mazich Kenneth
• Towler Jeffrey C
• Zhang Ji

Classifications

• A61K31/765

  Polymers containing oxygen · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• A61L31/148 Primary

  Materials at least partially resorbable by the body · CPC title

• A61L31/10

  Macromolecular materials · CPC title

• A61L2/087

  Particle radiation, e.g. electron-beam, alpha or beta radiation · CPC title