Lymphoma prognostic methods and kits

Patent metadata

Field	Value
Publication number	US-2017081726-A1
Application number	US-201615268938-A
Country	US
Kind code	A1
Filing date	Sep 19, 2016
Priority date	Jun 22, 2012
Publication date	Mar 23, 2017
Grant date	—

Abstract

This disclosure describes, in one aspect, a method that, in general, includes analyzing a tumor tissue sample from a subject for expression of at least two biomarkers, wherein a predetermined ratio of expression of the at least two biomarkers identifies the tumor tissue sample as coming from a subject having a particular subtype of lymphoma; and identifying the subject as having a particular subtype of lymphoma.

First claim

1 - 25 . (canceled)

26 . A kit for determining prognosis of a subject, the kit comprising:
reagents for measuring expression of a plurality of predictive coding regions in a sample from the subject, the plurality of predictive coding regions comprising at least one of:
a combination of CD28 and ABCA5; or
a combination of CCDC3 and SMOC2.

27 . The kit of claim 26 wherein the reagents for measuring expression of a plurality of predictive coding regions comprises reagents for performing Northern blotting, nuclease protection assay, DNA microarray, serial analysis of gene expression, quantitative reverse transcription-polymerase chain reaction (RT-PCR), differential-display RT-PCR, massively parallel signature sequencing, or real-time quantitative PCR.

28 . The kit of claim 26 wherein the reagents for measuring expression of a plurality of predictive coding regions comprises reagents for performing protein expression analysis.

29 - 34 . (canceled)

Assignees

• Univ Minnesota

Inventors

• Modiano Jaime Freddy
• Frantz Aric Mathew
• O'Brien Timothy David
• Sarver Aaron Lyman

Classifications

• C12Q2600/118

  Prognosis of disease development · CPC title

• A61K38/50

  acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase · CPC title

• A61K31/704

  attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin {(digitoxin A61K31/7048)} · CPC title

• A61K31/664

  Amides of phosphorus acids · CPC title

• A61K31/655

  Azo (—N=N—), diazo (=N2), azoxy (>N—O—N< or N(=O)—N<), azido (—N3) or diazoamino (—N=N—N<) compounds · CPC title