Apparatus and Method For Delivery of Antimicrobial During a Transdermal Sampling and Delivery Process

Patent metadata

Field	Value
Publication number	US-2017035331-A1
Application number	US-201615226475-A
Country	US
Kind code	A1
Filing date	Aug 2, 2016
Priority date	Aug 3, 2015
Publication date	Feb 9, 2017
Grant date	—

Abstract

A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid includes a substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for forming a micropore in the user's skin. A nanofiber mat loaded with at least one antimicrobial material is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element. In a preferred embodiment, the at least one antimicrobial material is LL-37.

First claim

1 . A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid of a user comprising:
a substrate having thereon
a mechanism for accessing the interstitial fluid of the user; and
a nanofiber mat loaded with at least one antimicrobial material.

2 . The device of claim 1 , wherein the mechanism includes at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion.

3 . The device of claim 2 , wherein the microheating element causes a micropore in the user's skin.

4 . The device of claim 3 , wherein the nanofiber mat is generally ring shaped and is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element.

5 . The device of claim 4 , wherein the nanofiber mat is loaded with more than one antimicrobial material.

6 . The device of claim 5 , wherein one of the at least one antimicrobial material is LL-37.

7 . The device of claim 1 , wherein the substrate includes thereon multiple individually controllable sites for accessing interstitial fluid of a user, each of the multiple individually controllable sites including:
a mechanism for accessing the interstitial fluid of the user; and a nanofiber mat loaded with at least one antimicrobial material.

8 . The device of claim 7 , wherein the mechanism includes at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion.

9 . The device of claim 8 , wherein the microheating element causes a micropore in the user's skin.

10 . The device of claim 9 , wherein the nanofiber mat is generally ring shaped and is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element.

11 . The device of claim 10 , wherein the nanofiber mat is loaded with more than one antimicrobial material.

12 . The device of claim 11 , wherein one of the at least one antimicrobial material is LL-37.

13 . A hand-held device for electrochemically monitoring an analyte in interstitial fluid of a user comprising:
a first end configured to contact the skin of the user, the first end including a mechanism for ablating the skin of the user to form a micropore to access interstitial fluid and further including a nanofiber mat formed thereon, the nanofiber mat including at least one antimicrobial material; a cartridge connected to the first end and having disposed therein a plurality of disposable sensing elements for contacting interstitial fluid from the micropore to monitor an analyte therein; a second end connected electrically and mechanically to the cartridge and the first end for facilitating operation of the mechanism for ablating the skin, dispensing of a disposable sensing element and monitoring of the analyte.

14 . The hand-held device of claim 13 , wherein the mechanism for ablating the skin includes at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion located at an open-ended tip of the first end.

15 . The device of claim 14 , wherein the nanofiber mat is generally ring shaped and is arranged on the tip of the first end such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element.

16 . The device of claim 15 , wherein the nanofiber mat is loaded with more than one antimicrobial material.

17 . The device of claim 16 , wherein one of the at least one antimicrobial material is LL-37.

18 . A patch including multiple individually controllable sites for accessing interstitial fluid of a user and monitoring at least one analyte therein, comprising:
a substrate having formed thereon the multiple individually controllable sites each including:
a mechanism for producing a micropore in the user's skin and accessing the interstitial fluid of the user; and
a nanofiber mat loaded with at least one antimicrobial material; and
an adhesive for adhering the patch to the skin of the user.

19 . The patch of claim 18 , wherein the mechanism includes at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion.

20 . The device of claim 9 , wherein the nanofiber mat is generally ring shaped and is arranged on the substrate such that it contacts the user's skin and encircles an opening of the micropore formed by the microheating element; and further wherein the at least one antimicrobial material is LL-37.

21 . A device for introducing at least one antimicrobial in an exposed region of a user's skin caused while accessing interstitial fluid of a user comprising:
a first substrate having thereon at least one electrically controllable microheating element including at least a microheater portion with multiple electrodes connected to the microheater portion for accessing the interstitial fluid of the user, the first substrate including a first hole therethough which is aligned with the microheater portion of the microheating element; and a second substrate having a nanofiber material containing at least one antimicrobial applied thereto, the second substrate further including a second hole therethrough which is aligned with the microheater portion of the microheating element; the first and second substrates being aligned back to back such that the microheating element is furthest from the user's skin and the nanofiber material is in contact with the user's skin.

22 . The device of claim 21 , wherein one of the at least one antimicrobial is LL-37.

Assignees

• Univ Georgetown

Inventors

• Paranjape Makarand
• Paranjape Shruti M

Classifications

• A61B5/157

  {Devices} characterised by integrated means for measuring characteristics of blood · CPC title

• A61B5/150969

  Low-profile devices which resemble patches or plasters, e.g. also allowing collection of blood samples for testing · CPC title

• A61B5/150328

  by aseptic fluid · CPC title

• A61B5/1477

  non-invasive · CPC title

• A61B5/14514 Primary

  using means for aiding extraction of interstitial fluid, e.g. microneedles or suction · CPC title