Devices and methods for ablation of tissue

Patent metadata

Field	Value
Publication number	US-2016374754-A1
Application number	US-201414892035-A
Country	US
Kind code	A1
Filing date	May 20, 2014
Priority date	May 20, 2013
Publication date	Dec 29, 2016
Grant date	—

Abstract

This document provides devices and methods for the treatment of heart conditions, hypertension, and other medical disorders. For example, this document provides devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation.

First claim

1 . A catheter-based medical device for treating a tissue, the device comprising:
an elongate catheter shaft including a liquid delivery lumen therethrough; a balloon device disposed at a distal end portion of said catheter shaft, said balloon device comprising an outer surface and an inner surface, said inner surface defining an interior space of said balloon device, said balloon device in fluid communication with said liquid delivery lumen, said balloon device comprising a porous or microporous material that is arranged to transmit a liquid through said porous or microporous material; and one or more electrodes that are disposed on or within said balloon device and are arranged to deliver energy to said tissue.

2 . The catheter-based medical device of claim 1 , wherein said one or more electrodes is a single electrode disposed on said catheter shaft and in said interior space.

3 . The catheter-based medical device of claim 2 , wherein said single electrode is arranged to transmit radio frequency energy for ablation of said tissue.

4 . The catheter-based medical device of claim 1 , wherein said one or more electrodes is a plurality of electrodes disposed on said outer surface.

5 . The catheter-based medical device of claim 4 , wherein said plurality of electrodes comprise at least one electrode that is arranged to transmit radio frequency energy for ablation of said tissue and at least one electrode that is arranged to transmit direct current electrical energy.

6 . The catheter-based medical device of claim 1 , wherein said one or more electrodes comprises (i) a single electrode disposed on said catheter shaft and in said interior space and (ii) plurality of electrodes disposed on said outer surface.

7 . The catheter-based medical device of claim 6 , wherein said single electrode is arranged to transmit radio frequency energy for ablation of said tissue, and said plurality of electrodes comprise at least one electrode that is arranged to transmit direct current electrical energy.

8 . (canceled)

9 . The catheter-based medical device of claim 1 , wherein said balloon device has a bulbous-shaped proximal portion and a generally cylindrical-shaped distal portion when said balloon is inflated, and wherein said bulbous-shaped proximal portion and said generally cylindrical-shaped distal portion are in fluid communication.

10 . (canceled)

11 . A method for ablating a tissue of a patient, said method comprising:
inserting a catheter-based medical device into said patient, said medical device comprising:
an elongate catheter shaft including a liquid delivery lumen therethrough;
a balloon device disposed at a distal end of said catheter shaft, said balloon device comprising an outer surface and an inner surface, said inner surface defining an interior space of said balloon device, said balloon device in fluid communication with said liquid delivery lumen, said balloon device comprising a porous or microporous material that is arranged to exude a liquid through said porous or microporous material; and
one or more electrodes that are disposed on or within said balloon device and are arranged to deliver energy to said tissue;
deploying said balloon device near said tissue; supplying a pharmacological agent through said liquid delivery lumen to said interior space thereby causing inflation of said balloon device and causing said pharmacological agent to exude from said interior space to said outer surface; and energizing at least a first one of said one or more electrodes, wherein said energizing provides an energy sufficient for ablation of at least a portion of said tissue.

12 . The method of claim 11 , wherein at least a portion of said energizing at least a first one of said one or more electrodes takes place while said pharmacological agent is exuding from said interior space to said outer surface.

13 . The method of claim 11 , wherein said pharmacological agent transmits at least a portion of said energy sufficient for ablation of at least a portion of said tissue.

14 . The method of claim 11 , further comprising energizing at least a second one of said one or more electrodes, wherein said energizing at least a second one of said one or more electrodes comprises supplying direct current electricity energy sufficient for enhancing an uptake of said pharmacological agent by said tissue.

15 . The method of claim 11 , wherein said tissue is a pulmonary vein.

16 . The method of claim 11 , wherein said pharmacological agent is an antimitotic pharmacological agent.

17 . The method of claim 11 , wherein said tissue is a left atrial appendage.

18 . The method of claim 11 , wherein said tissue is a renal artery.

19 .- 22 . (canceled)

23 . A catheter-based medical device for treating a tissue, the device comprising:
an elongate catheter shaft including a liquid delivery lumen therethrough; a balloon device disposed at a distal end portion of said catheter shaft, said balloon device comprising an outer surface and an inner surface, said inner surface defining an interior space of said balloon device, said balloon device in fluid communication with said liquid delivery lumen, said balloon device comprising a porous or microporous material that is arranged to transmit a liquid through said porous or microporous material; one or more electrodes that are disposed on or within said balloon device and are arranged to deliver energy to said tissue; and a filter device, said filter device being deployable from said catheter shaft and generally coaxial with said balloon device, and wherein a distal end portion of said filter device is configured to contact a tissue surface surrounding said tissue.

24 . The catheter-based medical device of claim 23 , wherein said balloon device is configured to extend distally of said filter device when said filter device and said balloon device are extended from said catheter shaft in a configuration to treat said tissue.

25 .- 32 . (canceled)

33 . The catheter-based medical device of claim 23 , wherein said balloon device has a bulbous-shaped proximal portion and a generally cylindrical-shaped distal portion when said balloon is inflated, and wherein at least a portion of said filter device is configured to surround said bulbous-shaped proximal portion when said filter device is in an expanded configuration.

34 . The catheter-based medical device of claim 23 , wherein said filter device is configured to substantially prevent blood from flowing through said filter device.

Assignees

• Mayo Foundation

Inventors

• Asirvatham Samuel J
• Holmes Jr David R

Classifications

• A61B2090/3966

  Radiopaque markers visible in an X-ray image · CPC title

• A61N1/306

  Arrangements where at least part of the apparatus is introduced into the body · CPC title

• A61B2018/00065

  porous · CPC title

• A61B2018/00375

  Ostium, e.g. ostium of pulmonary vein or artery · CPC title

• A61B2018/00154

  containing and delivering drugs · CPC title