System for monitoring a dopaminergic activity

Patent metadata

Field	Value
Publication number	US-2016374594-A1
Application number	US-201615194554-A
Country	US
Kind code	A1
Filing date	Jun 27, 2016
Priority date	Jun 26, 2015
Publication date	Dec 29, 2016
Grant date	—

Abstract

The present invention relates to a system for monitoring a dopaminergic activity of a subject, wherein the system comprises a detection unit for detecting an eye blink signal relating to eye blinks of the subject; an analysis unit for determining, based on the detected eye blink signal, an eye blink feature indicative of the dopaminergic activity of the subject and for comparing the eye blink feature with a reference eye blink feature; and a feedback unit for providing feedback relating to the dopaminergic activity of the subject based on the comparison of the eye blink feature and the reference eye blink feature. Further aspects of the present invention relate to a corresponding method and computer program. The approach permits early screening of a dopaminergic activity and continuous monitoring of the patient's response to dopamine drugs, for example.

First claim

What is claimed is:

1 . A system for monitoring a dopaminergic activity of a subject, the system comprising:
a detection unit for detecting an eye blink signal relating to one or more eye blinks of the subject: an analysis unit for determining, based on the detected eye blink signal, an eye blink feature indicative of the dopaminergic activity of the subject and for comparing the eye blink feature with a reference eye blink feature; and a feedback unit for providing feedback relating to the dopaminergic activity of the subject based on the comparison of the eye blink feature and the reference eye blink feature.

2 . The system according to claim 1 , wherein the eye blink feature comprises an eye blink rate.

3 . The system according to claim 1 , wherein the feedback unit is configured to at least one of provide a recommendation relating to an adjustment of a dose of a dopaminergic activity agent or initiate treatment.

4 . The system according to claim 1 , wherein the detection unit comprises at least one of a camera or an electrode.

5 . The system according to claim 1 , wherein the detection unit is comprised in a wearable device.

6 . The system according to claim 5 , wherein the detection unit is comprised in a head-mounted device comprising at least one of a nasal support or an oral support.

7 . The system according to claim 6 , wherein the at least one nasal support or oral support comprises an electrode of the detection unit.

8 . The system according to claim 1 , wherein the analysis unit is configured to identify spontaneous eye blinks in the eye blink signal and to determine a spontaneous eye blink rate as the eye blink feature.

9 . The system according to claim 1 , wherein the analysis unit is configured to identify at least one of spontaneous, voluntary or reflex eye blinks in the eye blink signal based of one or more signal features relating to the at least one of spontaneous, voluntary or reflex eye blinks.

10 . The system according to claim 1 , further comprising a stimulus unit structured and configured for evoking a reflex eye blink.

11 . The system according to claim 1 , wherein the analysis unit is configured to obtain the reference eye blink feature from at least one of a previously determined eye blink feature of the subject, a historic patient database or a research database.

12 . The system according to claim 1 , wherein the analysis unit is configured to determine a time of day and to compare the eye blink feature with the reference eye blink feature based on the time of day.

13 . The system according to claim 1 , wherein the analysis unit is configured to determine a circadian phase of the subject and to compare the eye blink feature with the reference eye blink feature based on the circadian phase of the subject.

14 . A method for monitoring a dopaminergic activity of a subject, comprising the steps of:
receiving an eye blink signal relating to one or more eye blinks of the subject; determining, based on the received eye blink signal, an eye blink feature indicative of the dopaminergic activity of the subject; comparing the eye blink feature with a reference eye blink feature; and providing feedback relating to the dopaminergic activity of the subject based on the comparison of the eye blink feature and the reference eye blink feature.

15 . A computer program comprising executable program code structured and configured for causing a computer to carry out the steps of the method according to claim 14 when the computer program is executed on a computer.

Assignees

• Koninklijke Philips Nv

Inventors

• Garcia Molina Gary Nelson
• Aarts Ronaldus Maria

Classifications

• A61B5/1103 Primary

  Detecting muscular movement of the eye, e.g. eyelid movement · CPC title

• A61B5/0496

  Human Necessities · mapped topic

• A61B5/6803

  Head-worn items, e.g. helmets, masks, headphones or goggles · CPC title

• A61B5/4839

  combined with drug delivery · CPC title

• A61B5/1118

  Determining activity level · CPC title