Nanoparticles comprised of shells associated with charged entities and formed from monomers and methods of making and using nanoparticles

Patent metadata

Field	Value
Publication number	US-2016367705-A1
Application number	US-201615184822-A
Country	US
Kind code	A1
Filing date	Jun 16, 2016
Priority date	Jun 16, 2015
Publication date	Dec 22, 2016
Grant date	—

Abstract

The present invention relates to relates to a nanoparticle that includes a shell formed from a first monomer having a first charge and a second monomer different than the first monomer. The first and second monomers are copolymerized, and the shell encapsulates a core region and is associated with a charged entity having a second charge of opposite sign to the first charge. The present invention further relates to a nanoparticle having a neutral charge. The present invention further relates to nanoparticle dispersions, methods of making the nanoparticle, methods of method of imaging, methods of delivering drugs, and methods of delivering a high concentration of contrast enhancing and/or imaging agents.

First claim

1 . A nanoparticle comprising:
a shell formed from a first monomer having a first charge and a second monomer different than the first monomer, said first and second monomers being copolymerized, wherein said shell encapsulates a core region and is associated with a charged entity having a second charge of opposite sign to the first charge.

2 . The nanoparticle of claim 1 , wherein the charged entity is derived from a surfactant.

3 . The nanoparticle of claim 2 , wherein the charged entity is derived from a cationic surfactant selected from the group consisting of C 12 -C 18 alkyl dimethylammonium acetamide, C 12 -C 18 alkyl trimethylammonium, and mixtures thereof.

4 . The nanoparticle of claim 1 , wherein the charged entity is a charged substituent.

5 . The nanoparticle of claim 4 , wherein the charged substituent is a metal selected from the group consisting of silver, gold, copper, platinum, iron, manganese, cobalt, and mixtures thereof.

6 . The nanoparticle of claim 1 , wherein the first monomer and the second monomer are covalently linked.

7 . The nanoparticle of claim 1 , wherein the first charge is negative and the second charge is positive.

8 . The nanoparticle of claim 1 , wherein the first charge is positive and the second charge is negative.

9 . (canceled)

10 . The nanoparticle of claim 1 , wherein the first monomer is a deprotonated sugar acid comprising three or more hydroxyl groups.

11 . The nanoparticle of claim 1 , wherein the first monomer is selected from the group consisting of carboxylic acids, amines, alcohols, thiols, aldehydes, ketones, ethers, esters, nitriles, imides, or any salt thereof.

12 . (canceled)

13 . The nanoparticle of claim 1 , wherein the ratio of the first monomer to the charged entity is in the range of 3:1 to 1:3.

14 . The nanoparticle of claim 1 , wherein the nanoparticle is a hyperbranched polymeric nanoparticle.

15 . The nanoparticle of claim 1 , wherein the nanoparticle is a reticulated capsule.

16 . The nanoparticle of claim 1 , where the core region contains a core material selected from the group consisting of water, organic molecules, dye molecules, drugs, inorganic ions, organic ions, water soluble species, metals, and combinations thereof.

17 .- 23 . (canceled)

24 . A nanoparticle comprising:
a shell formed from a first monomer and a second monomer different from the first monomer, said first and second monomer being copolymerized, wherein said shell encapsulates a core region and has a neutral charge.

25 .- 26 . (canceled)

27 . A dispersion comprising:
the nanoparticle of claim 1 and a medium selected from the group consisting of water, methanol, dimethyl sulfoxide, chloroform, methylene chloride, and mixtures thereof, wherein the nanoparticle is dispersed in the medium.

28 . A method of making a nanoparticle, said method comprising:
providing a first monomer having a first charge; providing a charged entity having a second charge of opposite sign to the first charge; contacting the first monomer with the charged entity in an aqueous medium under conditions effective to form a complex where the first monomer is associated with the charged entity; providing a second monomer; and contacting the complex with the second monomer under conditions effective to form a shell of the first and second monomers which have been copolymerized, said shell encapsulating a core region containing an aqueous medium.

29 .- 38 . (canceled)

39 . A method of imaging comprising:
providing the nanoparticle of claim 1 , wherein the nanoparticle encapsulates an imaging agent in the core region; providing a subject to be imaged; administering the nanoparticle to said subject; and conducting an imaging procedure on said subject to which the nanoparticles have been administered.

40 .- 44 . (canceled)

45 . A method of delivering drugs, said method comprising:
providing the nanoparticle of claim 1 with a drug encapsulated in the core; providing a subject to be treated; and administering to a subject the nanoparticle under conditions effective to deliver drugs.

46 . A method of delivering a high concentration of contrast enhancing and/or imaging agents, said method comprising:
providing the nanoparticle of claim 1 with a contrast enhancing and/or imaging agent encapsulated in the core; providing a subject to be treated; and administering to the subject the nanoparticle.

Assignees

• Walters Marc
• Univ New York

Inventors

• Walters Marc

Classifications

• A61K9/5123

  Organic compounds, e.g. fats, sugars · CPC title

• A61K9/5146

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides · CPC title

• A61K49/1857 Primary

  the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA · CPC title

• A61K9/5115

  Inorganic compounds · CPC title

• A61K9/5089

  Processes · CPC title