Cytotoxic benzodiazepine derivatives

Patent metadata

Field	Value
Publication number	US-2016367698-A1
Application number	US-201615170428-A
Country	US
Kind code	A1
Filing date	Jun 1, 2016
Priority date	Sep 3, 2014
Publication date	Dec 22, 2016
Grant date	—

Abstract

The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

First claim

1 . A compound represented by any one of the following formulas:

or a pharmaceutically acceptable salt thereof, wherein:
the double line between N and C represents a single bond or a double bond, provided that when it is a double bond, X is absent and Y is —H, and when it is a single bond, X is selected from —H;
Y is —H, —SO 3 M or —OH wherein M is —H or a cation;
X′ is —H;
Y′ is —H…

Assignees

• Immunogen Inc

Inventors

• Chari Ravi V J
• Miller Michael Louis
• Shizuka Manami

Classifications

• A61P37/06

  Human Necessities · mapped topic

• A61P35/00

  Human Necessities · mapped topic

• A61P29/00

  Human Necessities · mapped topic

• A61P31/04

  Human Necessities · mapped topic

• A61P31/12

  Human Necessities · mapped topic