IL2Rbeta/Common Gamma Chain Antibodies

Patent metadata

Field	Value
Publication number	US-2016367664-A1
Application number	US-201615229336-A
Country	US
Kind code	A1
Filing date	Aug 5, 2016
Priority date	Aug 6, 2015
Publication date	Dec 22, 2016
Grant date	—

Abstract

Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.

First claim

1 - 76 . (canceled)

77 . A method of treating cancer comprising administering an antibody or antigen binding fragment to a patient suffering from a cancer, wherein the antibody or antigen binding fragment is capable of binding to CD122 and common γ chain (γc).

78 . The method of claim 77 , wherein the antibody or antigen binding fragment is a bispecific antibody or a bispecific antigen binding fragment comprising:
(a) an antigen binding fragment which is capable of binding to CD122, and (b) an antigen binding fragment which is capable of binding to common γ chain (γc).

79 . The method of claim 77 , wherein the antibody or antigen binding fragment is a bispecific antibody or a bispecific antigen binding fragment comprising:
(a) an antigen binding fragment which is capable of binding to CD122, the antigen binding fragment comprising the amino acid sequences i) to vi):

i) LC-CDR1:

(SEQ ID NO: 85)

TGTSSDIGX 1 YDFX 2 S

(SEQ ID NO: 6)

RAGQAISSWLA;

(SEQ ID NO: 10)

QASQDIGNYLN;

or

(SEQ ID NO: 14)

TRSSGSIASNYVQ;

ii) LC-CDR2:

(SEQ ID NO: 86)

DX 3 NNRX 4 S;

(SEQ ID NO: 7)

KASNLES;

(SEQ ID NO: 11)

DASNLET;

or

(SEQ ID NO: 15)

DDNQRPT;

iii) LC-CDR3:

(SEQ ID NO: 87)

SAYTSSDTX 5 V;

(SEQ ID NO: 8)

QQYQSYPYT;

(SEQ ID NO: 12)

LQLYDYPLT;

or

(SEQ ID NO: 16)

QSSHSTAVV;

iv) HC-CDR1:

(SEQ ID NO: 88)

NYYX 6 H;

(SEQ ID NO: 40)

TYAMH;

(SEQ ID NO: 44)

SYAMS;

or

(SEQ ID NO: 48)

GYYWS;

v) HC-CDR2:

(SEQ ID NO: 37)

AIMPSRGGTSYPQKFQG;

(SEQ ID NO: 41)

WINTGNGNTKYSQNFQG;

(SEQ ID NO: 45)

AISGSGGSTYYADSVKG;

or

(SEQ ID NO: 49)

EINHSGSTNYNPSLKS;

vi) HC-CDR3:

(SEQ ID NO: 89)

GEYYYDSSGYYX 7 ;

(SEQ ID NO: 42)

DLGQLERLYFW;

(SEQ ID NO: 46)

Assignees

• Agency Science Tech & Res

Inventors

• Wang Cheng-I
• Brauer Peter
• Yeo Siok Ping
• Tan Hwee Ching
• CONNOLLY John Edward

Classifications

• A61P31/00

  Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• C07K16/112

  Retroviridae (F), e.g. leukemia viruses · CPC title

• A61K38/1709

  from mammals · CPC title

• C07K2317/64

  comprising a combination of variable region and constant region components · CPC title