Pyridazinedione-based heterobicyclic covalent linkers and methods and applications thereof
US-2024425465-A1 · Dec 26, 2024 · US
US2016362425A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016362425-A1 |
| Application number | US-201615150999-A |
| Country | US |
| Kind code | A1 |
| Filing date | May 10, 2016 |
| Priority date | May 11, 2015 |
| Publication date | Dec 15, 2016 |
| Grant date | — |
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The present invention is related to crystalline forms of (S)-7-(1-(9H-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one which is a PI3K inhibitor useful in the treatment of cancer and other diseases.
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What is claimed is: 1 . A crystalline form of the compound (S)-7-(1-(9H-purin-6-ylamino)ethyl)-6-(3-fluorophenyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one which is hydrated. 2 . The crystalline form of claim 1 which is a hemihydrate. 3 . The crystalline form of claim 1 which is Form VI. 4 . The crystalline form of claim 1 having an X-ray powder diffraction pattern comprising at least one peak, in terms of 2…
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