Scroll composite having amphiphilic substance inside and method for preparation of the same

Patent metadata

Field	Value
Publication number	US-2016355401-A1
Application number	US-201515117575-A
Country	US
Kind code	A1
Filing date	Mar 2, 2015
Priority date	Mar 4, 2014
Publication date	Dec 8, 2016
Grant date	—

Abstract

Provided are a scroll preparing method using a two-dimensional material and a scroll prepared thereby. The scroll preparing method comprises preparing a two-dimensional material. The two-dimensional material is scrolled by providing an amphiphilic substance having a hydrophilic portion and a hydrophobic portion on the two-dimensional material. As a result, a scroll composite including the amphiphilic substance disposed inside a scroll structure is formed.

First claim

1 . A scroll composite, comprising:
a two-dimensional material scroll with open ends; and an amphiphilic substance disposed inside the scroll.

2 . The composite of claim 1 , wherein the two-dimensional material is a single substance selected from the group consisting of graphene, graphene oxide, boron nitride, boron carbon nitride (BCN), tungsten oxide (WO 3 ), tungsten sulfide (WS 2 ), molybdenum sulfide (MoS 2 ), molybdenum telluride (MoTe 2 ), and manganese oxide (MnO 2 ), or a composite substance including a stack of two or more thereof.

3 . The composite of claim 1 , wherein the amphiphilic substance is a surfactant, a bile acid, a bile acid salt, a hydrate of a bile acid salt, a bile acid ester, a bile acid derivative, or a bacteriophage.

4 . The composite of claim 3 , wherein the surfactant includes one or more compounds selected from the group consisting of sodium dodecyl sulfate (SDS), ammonium lauryl sulfate, sodium laureth sulfate, alkyl benzene sulfonate, cetyl trimethylammonium bromide (CTAB), hexadecyl trimethyl ammonium bromide, an alkyltrimethylammonium salt, cetylpyridinium chloride (CPCl), polyethoxylated tallow amine (POEA), benzalkonium chloride (BAC), benzethonium chloride (BZT), dodecyl betaine, dodecyl dimethylamine oxide, cocamidopropyl betaine, alkyl poly(ethylene oxide), a poloxamer, a poloxamine, alkyl polyglucoside, cetyl alcohol, sodium deoxycholate, cocamide MEA, cocamide DEA, sorbitan ester, polyoxyethylene sorbitan fatty acid ester, sucrose fatty acid ester, polyethyelene glycol hydroxystearate, polyoxyethylene glycolated natural or hydrogenated castor oil, a polyoxyethylene-polyoxypropylene copolymer, a synthetic vitamin E derivative, polyoxyethylene alkyl ester, fatty acid microgol glyceride, polyglyceryl fatty acid ester, and a silicone-based surfactant.

5 . The composite of claim 3 , wherein the bile acid is represented by Formula 1 as follows:

where R 1 and R 2 are each independently —H or —OH, R 3 is —(CONH—(CH 2 ) n1 ) n2 —Y 1 , n1 is 1 or 2, n2 is 1 or 0, and Y 1 is —COOH or —SO 3 H.

6 . The composite of claim 5 , wherein the bile acid is at least one selected from the group consisting of cholic acid, chenodeoxycholic acid, deoxycholic acid, lithocholic acid, glycocholic acid, taurocholic acid, glycochenodeoxycholic acid, taurochenodeoxycholic acid, glycodeoxycholic acid, taurodeoxycholic acid, glycolithocholic acid, and taurolithocholic acid.

7 . The composite of claim 5 , wherein the bile acid salt is sodium glycochenodeoxycholate, sodium taurochenodeoxycholate, sodium taurocholate, sodium dehydrocholate, or sodium deoxycholate.

8 . The composite of claim 5 , wherein the hydrate of the bile acid salt is sodium taurocholate hydrate or sodium cholate hydrate.

9 . The composite of claim 3 , wherein the bile acid derivative is represented by Formula 2 below:

where n is 0, 1 or 2, and R 4 to R 7 are each independently a group represented by Formula 3,
B 1  m L 1  n G 1   [Formula 3]

where B 1 is one group selected from the group consisting of

L 1 is a linker of —W 1 —, -Q 1 -, -Q 2 -W 2 —, —W 2 -Q 1 -W 3 —, or —W 4 -Q 2 -W 5 -Q 3 -Q 6 -, W 1 , W 2 , W 3 , W 4 , W 5 , and W 6 are each independently

a 1 to a 3 are each an integer of 1 to 4, Q 1 , Q 2 , Q 3 , Q 4 , Q 5 , and Q 6 are each independently

G 1 is a group represented by

and
m is 0 or 1, and n is 0 or 1.

10 . The composite of claim 9 , wherein the bile acid derivative is any one of Formulas 4 to 20:

(R)—N-(aminomethyl)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamide

(R)-methyl-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoate

(R)-4-((3R,5R,8R,9S,103, 13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)-N-(hydroxymethyl)pentanamide

(R)—N-(aminomethyl)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamide

(R)-4-((3R,5R,7R,8R,9S,10S,13R,14S,17R)-7-hydroxy-10,13-dimethyl-3-(sulfooxy)hexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

5β-cholanic acid-3α,12α-diol 3-acetate methyl ester

5β-cholanic acid-3-one

5β-cholanic acid 3,7-dione methyl ester

5β-cholanic acid-3,7-dione

Carbamic(4R)-4-((3R,8R,9S,10S,13R,14S,17R)-3-hydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic anhydride

3R,7R,8R,9S,10S,12S,13R,14S,17R)-7,12-dihydroxy-10,13-dimethyl-17-((R)-5-((2-methyl-3-oxobutan-2-yl)amino)-5-oxopentan-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3-sulfonic acid

R)-4-oxo-7-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)octanenitrile

3-((R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamido)propanoic acid

(R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic sulfuric anhydride

(R)—N-carbamoyl-4-((3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanamide

4-((S)-1-((3R,5R,8R,9S,10S,12S,13S,1

Assignees

• Industry-Univ Coop Found Hanyang Univ

Inventors

• Suh Donghack
• Hwang Dayoung

Classifications

• C01B32/23

  Oxidation · CPC title

• C01P2004/20

  extending in two dimensions, e.g. plate-like · CPC title

• C01G41/02

  Oxides; Hydroxides · CPC title

• C01P2004/04

  obtained by TEM, STEM, STM or AFM · CPC title

• C07J41/0061

  one of the carbon atoms being part of an amide group · CPC title