Dynamic therapy delivery system

Patent metadata

Field	Value
Publication number	US-2016354588-A1
Application number	US-201615237742-A
Country	US
Kind code	A1
Filing date	Aug 16, 2016
Priority date	Feb 7, 2013
Publication date	Dec 8, 2016
Grant date	—

Abstract

Systems for delivery of therapeutic agents and related methods are disclosed. A sensing system is configured to detect a chemical in the vicinity of a patient and transmit a signal to a controller upon detection. A controller is configured to release a therapeutic agent which is transported to the site of interest. The controller communicates with an electronic medical records database, an alarm and a nurse call system.

First claim

1 .- 20 . (canceled)

21 . A therapy delivery patch comprising
a filter sheet for placement adjacent a patient's skin, an adhesive layer extending outwardly from the filter sheet and configured to attach to the patient's skin, a cover forming a space above the filter sheet, a therapeutic agent repository situated within the space, a flow controller situated within the space and operable to control a flow of therapeutic agent from the therapeutic agent repository through the filter sheet onto the patient's skin.

22 . The therapy delivery patch of claim 21 , wherein the flow controller is situated between the therapeutic agent repository and the filter sheet.

23 . The therapy delivery patch of claim 22 , wherein the flow controller comprises a valve.

24 . The therapy delivery patch of claim 22 , wherein the flow controller comprises a microfluidic pump.

25 . The therapy delivery patch of claim 21 , further comprising a processor situated in the space, the processor being configured to operate the flow controller to control the flow of therapeutic agent.

26 . The therapy delivery patch of claim 25 , further comprising at least one sensor that detects a chemical secretion of the patient.

27 . The therapy delivery patch of claim 26 , wherein the processor operates the flow controller to control the flow of therapeutic agent based on a signal received from the at least one sensor.

28 . The therapy delivery patch of claim 26 , wherein the at least one sensor extends through the filter sheet.

29 . The therapy delivery patch of claim 26 , wherein the at least one sensor is situated between the flow controller and the patient's skin.

30 . The therapy delivery patch of claim 26 , wherein the at least one sensor comprises one or more of the following: a metal oxide type semi-conductor (MOS) sensor, a capacitive sensor, an inductive sensor or a surface acoustic wave sensor.

31 . The therapy delivery patch of claim 26 , wherein the at least one sensor comprises a protein based biosensor.

32 . The therapy delivery patch of claim 31 , wherein the protein based biosensor comprises one or more of the following: an odarant binding protein (OBP), a sensory appendage protein (SAP), an odorant receptor, a gustatory receptor, a serpentine receptor, or an odarant degrading enzyme (ODE).

33 . The therapy deliver patch of claim 31 , wherein the at least one sensor further comprises an electrochemical transducer to generate an electrical signal in response to detection of a chemical by the protein based biosensor.

34 . The therapy delivery patch of claim 26 , wherein the at least one sensor detects an indication of Ischemia by detecting any one or more of the following: CO 2 , Urea, Urate, Chloride, Lactic Acid, CO 2 /O 2 or O 2 .

35 . The therapy delivery patch of claim 26 , wherein the at least one sensor detects a 1L-1α and Creatine Phosphokinase (CPK) which is indicative of wound development.

36 . The therapy delivery patch of claim 21 , wherein the therapeutic agent comprises a vasodilator.

37 . The therapy delivery patch of claim 36 , wherein the vasodilator comprises one or more of the following: histamine, niacin, potassium or nitric acid.

38 . The therapy delivery patch of claim 21 , wherein the cover forms a dome over the filter sheet.

39 . The therapy delivery patch of claim 38 , wherein a bottom of the dome is located near a junction between the adhesive layer and the filter sheet.

40 . The therapy delivery patch of claim 38 , wherein the therapeutic agent repository is situated between the flow controller and a top of the dome.

Assignees

• Hill Rom Services Inc

Inventors

• Ribble David L
• Gazagnes Laetitia
• Lachenbruch Charles A

Classifications

• A47C27/081

  of pneumatic type · CPC title

• A61M2205/3317

  Electromagnetic, inductive or dielectric measuring means · CPC title

• A61M2205/3303

  Using a biosensor · CPC title

• A61B5/4839

  combined with drug delivery · CPC title

• A61B5/6892

  Mats · CPC title