Method for manufacturing hollow needle-shaped body, and hollow needle-shaped body

Patent metadata

Field	Value
Publication number	US-2016354521-A1
Application number	US-201615241677-A
Country	US
Kind code	A1
Filing date	Aug 19, 2016
Priority date	Feb 24, 2014
Publication date	Dec 8, 2016
Grant date	—

Abstract

A method for manufacturing a hollow needle-shaped body includes producing a needle-shaped body having a substrate and a projection on a first surface of the substrate, and applying a laser beam to a second surface of the substrate opposite to the first surface such that a through hole that penetrates through the substrate and the projection is formed. The substrate and the projection are comprised of crystallized polyglycolic acid.

First claim

What is claimed is:

1 . A method for manufacturing a hollow needle-shaped body, comprising:
producing a needle-shaped body having a substrate and a projection on a first surface of the substrate; and applying a laser beam to a second surface of the substrate opposite to the first surface such that a through hole that penetrates through the substrate and the projection is formed, wherein the substrate and the projection comprise crystallized polygiycolic acid.

2 . The method of claim 1 , wherein the laser beam is an excimer laser beam.

3 . The method of claim 1 , wherein the needle-shaped body is produced such that a height from the first surface to an apex of the projection is in a range of from 0.5 mm to 2.0 mm.

4 . The method of claim 2 , wherein the needle-shaped body is produced such that a height from the first surface to an apex of the projection is in a range of from 0.5 mm to 2.0 mm.

5 . The method of claim 3 , wherein the needle-shaped body is produced such that the height divided by a maximum diameter of the projection at a connection of the projection and the substrate is in a range of from 1.1 to 5.

6 . The method of claim 4 , wherein the needle-shaped body is produced such that the height divided by a maximum diameter of the projection at a connection of the projection and the substrate is in a range of from 1.1 to 5.

7 . The method of claim 1 , wherein the crystallized polyglycolic acid has a degree of crystallization of 40% or more.

8 . The method of claim 2 , wherein the crystallized polyglycolic acid has a degree of crystallization of 40% or more.

9 . The method of claim 3 , wherein the crystallized polyglycolic acid has a degree of crystallization of 40% or more.

10 . The method of claim 4 , wherein the crystallized polyglycolic acid has a degree of crystallization of 40% or more.

11 . A hollow needle-shaped body, comprising:
a substrate; and a projection formed on a surface of the substrate, wherein the substrate and the projection have a through hole penetrating through the substrate and the projection and comprise crystallized polyglycolic acid.

12 . The hollow needle-shaped body of claim 11 , wherein a height from the surface of the substrate to an apex of the projection is in a range of from 0.5 mm to 2.0 mm.

13 . The hollow needle-shaped body of claim 12 , wherein the height divided by a maximum diameter of the projection at a connection of the projection and the substrate is in a range of from 1.1 to 5.

14 . The hollow needle-shaped body of claim 11 , wherein the crystallized polyglycolic acid has a degree of crystallization of 40% % or more.

15 . The hollow needle-shaped body of claim 12 , wherein the crystallized polyglycolic acid has a degree of crystallization of 40% or more.

16 . The hollow needle-shaped body of claim 13 , wherein the crystallized polyglycolic acid has a degree of crystallization of 40% or more.

17 . The hollow needle-shaped body of claim 14 , wherein the degree of crystallization of not more than 90%.

18 . The hollow needle-shaped body of claim 15 , wherein the degree of crystallization of not more than 90%.

19 . The hollow needle-shaped body of claim 16 , wherein the degree of crystallization of not more than 90%.

Assignees

• Toppan Printing Co Ltd

Inventors

• Sumida Tomoya

Classifications

• A61M2037/0023

  Drug applicators using microneedles · CPC title

• A61M2037/0053

  Methods for producing microneedles · CPC title

• B81C1/00111

  Tips, pillars, i.e. raised structures (microneedles A61M37/0015) · CPC title

• A61M37/0015

  by using microneedles · CPC title

• A61L31/06 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds {(A61L31/041 takes precedence)} · CPC title