Method for the preparation of biological tissue for dry use in an implant
US-2015282930-A1 · Oct 8, 2015 · US
Method for preparing biological tissue
US2016354519A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016354519-A1 |
| Application number | US-201615170528-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jun 1, 2016 |
| Priority date | Jun 8, 2015 |
| Publication date | Dec 8, 2016 |
| Grant date | — |
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Abstract
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A method for preparing tissue for medical applications, in particular for preparing tissue for use for an artificial heart valve using an α-galactosidase.
First claim
Opening claim text (preview).
What is claimed is: 1 . A method for preparing tissue for medical applications, in particular for preparing tissue for an artificial heart valve, the method comprising: decellularizing tissue by means of a detergent, treating the tissue with an α-galactosidase, and cross-linking collagen fibers of the tissue by means of a suitable cross-linking agent. 2 . The method according to claim 1 , characterized in that the α-galactosidase is an alkaline α-galactosidase. 3 . The method according to claim 1 , characterized in that the α-galactosidase originates from a GH-36 family. 4 . The method according to claim 1 , characterized in that the α-galactosidase originates from a GH-36 family, sub-group II. 5 . The method according to claim 1 , characterized in that the α-galactosidase originates from Cucumis Melo. 6 . The method according to claim 1 , characterized in that the detergent for decellularization contains at least one lipopeptide having amphiphilic properties, consisting essentially of a hydrophilic basic structure and a hydrophobic side chain. 7 . The method according to claim 1 , characterized in that the detergent for decellularization contains surfactin, daptomycin, caspofungin, arthrofactin, an echinocandin, an iturin, a syringomycin, a syringopeptide and/or a polymyxin. 8 . A method of using an α-galactosidase for the treatment of biological tissue for heart valve prostheses, the method comprising providing biological tissue for a heart valve prosthesis and treating the biological tissue with an α-galactosidase. 9 . The method according to claim 8 , characterized in that the α-galactosidase originates from the GH-36 family. 10 . The method according to claim 8 , characterized in that the α-galactosidase originates from Cucumis Melo. 11 . A biological tissue for heart valve prostheses produced according to the method of claim 1 . 12 . A biological tissue for heart valve prostheses produced according to the method of claim 8 .
Assignees
Inventors
Classifications
for artificial blood vessels (apparatus for applying cells on a blood vessel prosthesis A61F2/062) · CPC title
Collagen · CPC title
- A61L27/3687Primary
characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents · CPC title
Vascular tissue, e.g. heart valves · CPC title
Muscle tissue, e.g. sphincter · CPC title
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Frequently asked questions
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- What does patent US2016354519A1 cover?
- A method for preparing tissue for medical applications, in particular for preparing tissue for use for an artificial heart valve using an α-galactosidase.
- Who is the assignee on this patent?
- Biotronik Ag
- What technology area does this patent fall under?
- Primary CPC classification A61L27/3687. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Thu Dec 08 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 1 related publication on this page (citations in our corpus or others sharing the same primary CPC).