Method of making water soluble injectable calcium polyphosphate gels

Patent metadata

Field	Value
Publication number	US-2016354513-A1
Application number	US-201414900835-A
Country	US
Kind code	A1
Filing date	Jul 3, 2014
Priority date	Jul 3, 2013
Publication date	Dec 8, 2016
Grant date	—

Abstract

The present invention describes an injectable calcium polyphosphate (CPP) gel with dense structure, which can be applied as injectable bone void filler in medical field, such as orthopedic and dental applications. Amorphous CPP powder with fine particle size (<75 pm) can be completely dissolved in water, forming a homogeneous gelation phase separated from water phase. This homogeneous CPP gel with disentangled inorganic polyphosphate chains shows viscoelasticity and superior adhesion to natural bone, metal implant surfaces and other ceramic material surfaces. The CPP gel is biomimetic and biodegradable with strong osteoconductivity and osteoinductivity. The manufacturing procedure is easy and reproducible. The mechanical strength of CPP gel is controllable by modifications, such as sintering, incorporation of other biomaterials, etc.

First claim

1 - 47 . (canceled)

48 . A composition for bone or soft tissue repair, the composition comprising:
a colloid, the colloid being injectable and comprising amorphous calcium polyphosphate.

49 . The composition according to claim 48 , wherein the colloid is water soluble.

50 . The composition according to claim 48 , wherein the amorphous calcium polyphosphate has a degree of polymerization of about 100.

51 . The composition according to claim 48 , wherein the composition undergoes gelation after injection, and solidifies after about sixty minutes.

52 . The composition according to claim 48 , wherein the colloid is formed in an aqueous solution.

53 . The composition according to claim 48 , further comprising a drug to be released after injection of the composition.

54 . The composition according to claim 48 , wherein the drug is substantially fully released for at least 30 hours after injection.

55 . The composition according to claim 48 , further comprising at least one of a metal, an organic compound, a polymer, and an inorganic ceramic material.

56 . The composition according to claim 48 , further comprising a quantity of crystalline calcium polyphosphate to form a composite colloid.

57 . The composition according to claim 56 having a ratio of amorphous calcium polyphosphate to crystalline calcium polyphosphate between about 1:1 to about 10:1.

58 . The composition according to claim 57 , wherein the ratio of amorphous calcium polyphosphate to crystalline calcium polyphosphate is about 2:1.

59 . The composition according to claim 56 , wherein the composite colloid is formed in an aqueous solution.

60 . The composition according to claim 56 , wherein composite colloid comprises crystals of calcium polyphosphate dispersed therein.

61 . The composition according to claim 56 , wherein the composite colloid sets to a solid within about 200 seconds when dried at about 37 degrees Celsius.

62 . The composition according to claim 56 , further comprising at least one of a metal, an organic compound, a polymer, and an inorganic ceramic material.

63 . The composition according to claim 56 , further comprising a drug to be released after injection of the composition, the drug being substantially fully released for at least 150 hours after injection.

64 . A composition for bone or soft tissue repair, the composition comprising:
a colloid, the colloid being an injectable composite colloid comprising amorphous calcium polyphosphate and crystalline calcium polyphosphate in a predetermined ratio, the composite colloid being water soluble.

65 . The composition according to claim 64 , wherein the predetermined ratio of amorphous calcium polyphosphate is between about 1:1 and about 10:1.

66 . The composition according to claim 64 having a ratio of amorphous calcium polyphosphate:crystalline calcium polyphosphate:water of about 2:1:20.

67 . The composition according to claim 64 , wherein the composition has a porous structure after solidifying and setting.

Assignees

• Univ Wayne State

Inventors

• Ren Weiping
• Song Wei

Classifications

• A61L2430/34

  for soft tissue reconstruction · CPC title

• A61K9/5073

  having two or more different coatings optionally including drug-containing subcoatings · CPC title

• A61K9/1652

  Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin (homeopathic globules A61K9/1623) · CPC title

• A61L27/52

  Hydrogels or hydrocolloids · CPC title

• A61L27/12 Primary

  Phosphorus-containing materials, e.g. apatite · CPC title