Depth resolved scintillation detector array imaging apparatus and method of use thereof

Patent metadata

Field	Value
Publication number	US-2016354048-A1
Application number	US-201615243772-A
Country	US
Kind code	A1
Filing date	Aug 22, 2016
Priority date	May 22, 2008
Publication date	Dec 8, 2016
Grant date	—

Abstract

The invention comprises a method or apparatus for tomographically imaging a sample, such as a tumor of a patient, using positively charged particles. Position, energy, and/or vectors of the positively charged particles are determined using a plurality of scintillators, such as layers of chemically distinct scintillators where each chemically distinct scintillator emits photons of differing wavelengths upon energy transfer from the positively charged particles. Knowledge of position of a given scintillator type and a color of the emitted photon from the scintillator type allows a determination of residual energy of the charged particle energy in a scintillator detector. Optionally, a two-dimensional detector array additionally yields x/y-plane information, coupled with the z-axis energy information, about state of the positively charged particles. State of the positively charged particles as a function of relative sample/particle beam rotation is used in tomographic reconstruction of an image of the sample or the tumor.

First claim

1 . A method for imaging a tumor of a patient using positively charged particles, comprising:
providing a scintillator material, comprising the steps of:
a first scintillator comprising a first chemical composition at a first known position; and
a second scintillator comprising a second chemical composition at a second known position, said first chemical composition differing from said second chemical composition;
the positively charged particles longitudinally traversing a charged particle beam path from an accelerator, through the tumor, and into said scintillator material; optically coupling a first two-dimensional detector array to said scintillator material; said first two-dimensional detector array detecting:
first photons emitted, resultant from a first energy transfer from the positively charged particles, from said first known position yielding a first signal; and
second photons emitted, resultant from a second energy transfer from the positively charged particles, from said second known position yielding a second signal; and
determining a path of the positively charged particles using the first signal, the first known position, the second signal, and the second known position.

2 . The method of claim 1 , further comprising the steps of:
the positively charged particles penetrating a depth into n scintillator layers, of said scintillator material, said n scintillator layers sequentially positioned in the charged particle beam path, where n is a positive integer greater than one, wherein a first scintillator layer of said n scintillator layers comprises said first scintillator, and wherein a second scintillator layer of said n scintillator layers comprises said second scintillator.

3 . The method of claim 2 , said step of determining said path further comprising the steps of:
determining a depth of penetration, along a z-axis, of the positively charged particles into said scintillator material using the first signal and the second signal; and determining an x/y-plane position of the positively charged particles using at least one of the first signal and the second signal, said z-axes normal to said x/y-plane.

4 . The method of claim 3 , said step of determining said depth of penetration further comprising the step of:
relating the first signal from said first photons to a first known depth of the first known position of the first scintillator; and relating the second signal from said second photons to a second known depth of the second known position of the second scintillator.

5 . The method of claim 4 , the first signal comprising a first peak intensity at a first wavelength, the second signal comprising a second peak intensity at a second wavelength, said second wavelength at least ten nanometers longer than said first wavelength.

6 . The method of claim 4 , said step of determining a path of the positively charged particles further comprising the step of:
detecting the first photons and the second photons using a second two-dimensional detector array optically coupled to said scintillator material.

7 . The method of claim 6 , further comprising the step of:
imaging said scintillation material using said first two-dimensional detector array and said second two-dimensional detector array.

8 . The method of claim 9 , further comprising the steps of:
generating a set of signals as a function of rotation of the patient relative to said scintillator material; using the set of signals to determine paths of the positively charged particles through the tumor of the patient as a function of time; and forming a three-dimensional image of the tumor using tomographic reconstruction.

9 . The method of claim 8 , further comprising the step of:
at each of at least four rotation positions of the patient relative to the scintillation material, imaging the tumor of the patient using an X-ray imaging system.

10 . The method of claim 4 , further comprising the step of:
gating injection of the positively charged particles into said accelerator at intervals at least as long as a fifty percent quenching period of the first photons using a triode extraction system of an ion beam source.

11 . An apparatus for imaging a tumor of a patient using positively charged particles, comprising:
a scintillator material, comprising:
a first scintillator comprising a first chemical composition at a first known volume; and
a second scintillator comprising a second chemical composition at a second known volume, said first chemical composition differing from said second chemical composition;
a charged particle beam path from an accelerator, through a patient position, into said scintillator material; and a first two-dimensional detector array optically coupled to said scintillator material, wherein, during use, said first two-dimensional detector array detects:
first photons emitted, resultant from a first energy transfer from the positively charged particles, from said first known position yielding a first signal; and
second photons emitted, resultant from second energy transfer from the positively charged particles, from said second known position yielding a second signal, and
wherein a path of the positively charged particles is determined using the first signal, the first known position, the second signal, and the second known position.

12 . The apparatus of claim 11 , said first scintillator at said first known volume abutted against said second scintillator at said second known volume, the charge particle beam path traversing said first scintillator prior to passing into said second scintillator, during use.

13 . The apparatus of claim 12 , said scintillator material further comprising:
n scintillator layers sequentially positioned in the charged particle beam path,
where n is a positive integer greater than one,
a first layer of said n scintillator layers comprising said first scintillator volume, and
a second layer of said n scintillator layers comprising said second scintillator volume.

14 . The apparatus of claim 13 , wherein each of said n scintillation layers respectively comprises one of n scintillation materials, wherein n comprises an integer greater than two, wherein at least three of said n scintillation materials comprise different chemical compositions, at least one of said n scintillation materials comprising a doped iodide salt.

15 . The apparatus of claim 14 , further comprising:
a two-dimensional X-ray imaging system configured to simultaneously, with rotation of said scintillation material relative to the patient, rotate at least one of an X-ray source and an X-detector relative to the patient.

16 . The apparatus of claim 14 , further comprising:
a two-dimensional color filter array optically coupled to a detection face of said first two-dimensional detector array.

17 . The apparatus of claim 16 , said color filter array comprising one color filter type for each number of chemical compositions of said scintillator material.

18 . The apparatus of claim 15 , further comprising:
a set of two-dimensional detector arrays, comprising:
said first two-dimensional detector array; and
a second two-dimensional detector array optically coupled to said scintillator material,
said first two-dimensional detector array comprising a detection surface within twenty degrees of perpendicular to a detection face of said second two-dimensional detector array.

19 . The apparatus of claim 13 , said scintillator material further comprising:
a first thickness of said firs

Assignees

• Lee W Davis
• Amato Mark R

Inventors

• Lee W Davis
• Amato Mark R

Classifications

• A61N5/107

  in real time, i.e. during treatment · CPC title

• A61N2005/1054

  using a portal imaging system · CPC title

• A61N5/1067

  in real time, i.e. during treatment · CPC title

• A61N5/1077

  Beam delivery systems · CPC title

• G21K5/04

  with beam-forming means · CPC title