Nutrition composition suppressing growth of protozoan parasites of blood cells

Patent metadata

Field	Value
Publication number	US-2016353789-A1
Application number	US-201615244349-A
Country	US
Kind code	A1
Filing date	Aug 23, 2016
Priority date	Feb 24, 2014
Publication date	Dec 8, 2016
Grant date	—

Abstract

Compositions, comprising one or more amino acids selected from the group consisting of tryptophan, methionine, phenylalanine, valine, leucine, histidine, lysine and threonine, and isoleucine at a content of not more than 1.5 wt % relative to the total amount of the nutrition composition, provide a more economical and effective nutrition composition for suppressing the growth of hemocytozoon such as malaria parasite and the like.

First claim

1 . A nutrition composition, comprising:
(a) tryptophan, methionine, phenylalanine, valine, leucine, histidine, lysine, and threonine; and (b) optionally isoleucine, wherein when said isoleucine is present, it is present in an amount of not more than 1.5 wt % relative to the total amount of the nutrition composition.

2 . A nutrition composition, comprising:
(a) tryptophan, methionine, phenylalanine, valine, leucine, histidine, lysine, and threonine; and (b) optionally isoleucine, wherein when said isoleucine is present, it is present in an amount of not more than 3.8 wt % relative to the total amount of the amino acids.

3 . The nutrition composition according to claim 1 , which does not contain isoleucine.

4 . The nutrition composition according to claim 2 , which does not contain isoleucine.

5 . The nutrition composition according to claim 1 , further comprising one or more nutrients selected from the group consisting of carbohydrate, protein, fat, vitamin and mineral.

6 . The nutrition composition according to claim 2 , further comprising one or more nutrients selected from the group consisting of carbohydrate, protein, fat, vitamin and mineral.

7 . A method of suppressing the growth of a hemocytozoon, comprising administering, to a vertebrate in need thereof, an effective amount of a nutrition composition comprising:
(a) one or more amino acids selected from the group consisting of tryptophan, methionine, phenylalanine, valine, leucine, histidine, lysine, and threonine; and (b) optionally isoleucine, wherein when said isoleucine is present, it is present in an amount of not more than 1.5 wt % relative to the total amount of the nutrition composition.

8 . The method according to claim 7 , wherein the nutrition composition does not contain isoleucine.

9 . The method according to claim 7 , further comprising one or more nutrients selected from the group consisting of carbohydrate, protein, fat, vitamin and mineral.

10 . The method according to claim 7 , wherein the hemocytozoon is a malaria parasite.

11 . The method according to claim 7 , further comprising administering an effective amount of other antimalarial agent(s).

12 . The method according to claim 11 , wherein said other antimalarial agent is one or more medicaments selected from the group consisting of quinine hydrochloride, chloroquine, mefloquine, a sulfadoxine/pyrimethamine combination agent, an atovaquone/proguanil combination agent, artemisinin, artesunate, artemether, an artemether/lumefantrine combination agent and an artesunate/amodiaquine combination agent.

13 . A method of suppressing the growth of a hemocytozoon, comprising administering, to a vertebrate in need thereof, an effective amount of a nutrition composition comprising:
(a) one or more amino acids selected from the group consisting of tryptophan, methionine, phenylalanine, valine, leucine, histidine, lysine, and threonine; and (b) optionally isoleucine, wherein when said isoleucine is present, it is present in an amount of not more than 3.8 wt % relative to the total amount of the amino acids.

14 . The method according to claim 13 , wherein the nutrition composition does not contain isoleucine.

15 . The method according to claim 13 , further comprising one or more nutrients selected from the group consisting of carbohydrate, protein, fat, vitamin and mineral.

16 . The method according to claim 13 , wherein the hemocytozoon is a malaria parasite.

17 . The method according to claim 13 , further comprising administering an effective amount of other antimalarial agent(s).

18 . The method according to claim 17 , wherein said other antimalarial agent is one or more medicaments selected from the group consisting of quinine hydrochloride, chloroquine, mefloquine, a sulfadoxine/pyrimethamine combination agent, an atovaquone/proguanil combination agent, artemisinin, artesunate, artemether, an artemether/lumefantrine combination agent and an artesunate/amodiaquine combination agent.

19 . A method of treating infectious disease caused by hemocytozoon, comprising administering, to a vertebrate in need thereof, an effective amount of a nutrition composition comprising:
(a) one or more amino acids selected from the group consisting of tryptophan, methionine, phenylalanine, valine, leucine, histidine, lysine, and threonine; and (b) optionally isoleucine, wherein when said isoleucine is present, it is present in an amount of not more than 1.5 wt % relative to the total amount of the nutrition composition.

20 . The method according to claim 19 , wherein the nutrition composition does not contain isoleucine.

21 . The method according to claim 19 , further comprising one or more nutrients selected from the group consisting of carbohydrate, protein, fat, vitamin and mineral.

22 . The method according to claim 19 , wherein the hemocytozoon is a malaria parasite.

23 . The method according to claim 19 , further comprising administering an effective amount of other antimalarial agent(s).

24 . The method according to claim 23 , wherein said other antimalarial agent is one or more medicaments selected from the group consisting of quinine hydrochloride, chloroquine, mefloquine, a sulfadoxine/pyrimethamine combination agent, an atovaquone/proguanil combination agent, artemisinin, artesunate, artemether, an artemether/lumefantrine combination agent and an artesunate/amodiaquine combination agent.

25 . A method of treating infectious disease caused by hemocytozoon, comprising administering, to a vertebrate in need thereof, an effective amount of a nutrition composition comprising:
(a) one or more amino acids selected from the group consisting of tryptophan, methionine, phenylalanine, valine, leucine, histidine, lysine, and threonine; and (b) optionally isoleucine, wherein when said isoleucine is present, it is present in an amount of not more than 3.8 wt % relative to the total amount of the amino acids.

26 . The method according to claim 25 , wherein the nutrition composition does not contain isoleucine.

27 . The method according to claim 25 , further comprising one or more nutrients selected from the group consisting of carbohydrate, protein, fat, vitamin and mineral.

28 . The method according to claim 25 , wherein the hemocytozoon is a malaria parasite.

29 . The method according to claim 25 , further comprising administering an effective amount of other antimalarial agent(s).

30 . The method according to claim 29 , wherein said other antimalarial agent is one or more medicaments selected from the group consisting of quinine hydrochloride, chloroquine, mefloquine, a sulfadoxine/pyrimethamine combination agent, an atovaquone/proguanil combination agent, artemisinin, artesunate, artemether, an artemether/lumefantrine combination agent and an artesunate/amodiaquine combination agent.

Assignees

• Ajinomoto Kk

Inventors

• Bannai Makoto
• Nagao Kenji
• Kanuka Hirotaka

Classifications

• A61P33/02

  Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis · CPC title

• A61P33/06

  Antimalarials · CPC title

• A23L33/175 Primary

  Amino acids · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A61K31/405

  Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin · CPC title