Use of biomarkers to determine whether a subject has sustained, may have sustained or is suspected of sustaining a subacute acquired brain injury (abi)
US-2024337668-A1 · Oct 10, 2024 · US
US2016349275A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016349275-A1 |
| Application number | US-201515116179-A |
| Country | US |
| Kind code | A1 |
| Filing date | Feb 6, 2015 |
| Priority date | Feb 7, 2014 |
| Publication date | Dec 1, 2016 |
| Grant date | — |
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The present invention concerns subject matter connected to or making use of lgLON5, lgLON5 fragments and variants of lgLON5 and lgLON5-fragments. In particular the present invention relates to a use of a polypeptide comprising one or more sequences of IgLON5, an lgLON5-fragment or a variant thereof for the diagnosis of a disease, in vitro methods for diagnosing such a disease, a polypeptide comprising one or more sequences of lgLON5, an lgLON5-fragment or a variant thereof or a nucleic acid encoding said polypeptide for use in the treatment of a disease, a pharmaceutical composition comprising such polypeptide, a method for treating such a disease, an autoantibody binding to IgLON5, an lgLON5-fragment or a variant thereof, a method for isolating such autoantibody, a medical or diagnostic device comprising such autoantibody or such polypeptide and a test kit for the diagnosis of a disease, which test kit comprises such autoantibody and/or such polypeptide.
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1 . (canceled) 2 . A polypeptide comprising one or more sequences of IgLON5, an IgLON5-fragment, or a variant thereof or a nucleic acid encoding said polypeptide. 3 . An autoantibody binding to at least one of the polypeptides of claim 2 . 4 - 16 . (canceled) 17 . The polypeptide of claim 2 , wherein the sequence of IgLON5 is the sequence according to SEQ ID NO:1, and wherein the sequence of the IgLON5-frag…
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