Cross-sensitivity-compensated biosensor

Patent metadata

Field	Value
Publication number	US-2016349162-A1
Application number	US-201615169369-A
Country	US
Kind code	A1
Filing date	May 31, 2016
Priority date	Jun 1, 2015
Publication date	Dec 1, 2016
Grant date	—

Abstract

Embodiments of the invention include a biosensor, such as an implantable biosensor, that includes a sensor material sensitive to at least one analyte in a pressure measurement chamber coupled to a pressure sensor. In embodiments of the invention, a pressure prevailing in the pressure measurement chamber may be determined by the pressure sensor. The sensor material is coupled in the pressure measurement chamber to a compensation material, which includes a relationship between a temperature and a volume of the pressure. The relationship is opposite to a temperature-dependent change in pressure or volume of the sensor material and at least partially compensates for a cross-sensitivity-induced change in volume of the sensor material.

First claim

What is claimed is:

1 . A biosensor ( 10 ) comprising:
a sensor material ( 60 ); a pressure measurement chamber ( 20 ); and, a pressure sensor ( 56 );
wherein said sensor material ( 60 ) is sensitive to at least one analyte;
wherein said sensor material ( 60 ) is in the pressure measurement chamber ( 20 ),
wherein said pressure chamber ( 2 ) is coupled to the pressure sensor ( 56 ),
wherein a pressure prevailing in the pressure measurement chamber ( 20 ) is determined by the pressure sensor ( 56 ), and,
wherein the sensor material ( 60 ) in the pressure measurement chamber ( 20 ) is coupled to a compensation material ( 70 ), which at least partially compensates for a cross-sensitivity-induced change in volume of the sensor material ( 60 ).

2 . The biosensor according to claim 1 , wherein the cross-sensitivity-induced change in volume of the sensor material ( 60 ) is one or more of a temperature-induced change in volume and a pH value-induced change in volume.

3 . The biosensor according to claim 1 , wherein the sensor material ( 60 ) sensitive to at least one analyte is a polymer gel, or hydrogel, or a smart hydrogel sensitive to at least one analyte.

4 . The biosensor according to claim 1 , wherein a volume effect of the sensor material ( 60 ) based on one or more of a change to the pH value and a temperature change, and based on a change in concentration of the at least one analyte is detected at the sensor material ( 60 ).

5 . The biosensor according to claim 1 , wherein the pressure measurement chamber ( 20 ) comprises at least two compartments ( 22 , 24 ), wherein the sensor material ( 60 ) is arranged in a first of the two compartments ( 22 ) and the compensation material ( 70 ) is arranged in the second of the two compartments ( 24 ), and wherein the first compartment ( 22 ) comprises a region ( 30 ) which is permeable to the at least one analyte and a test medium.

6 . The biosensor according to claim 5 , wherein the at least two compartments ( 22 , 24 ) border one another, or further comprising a flexible membrane ( 40 ) arranged between the at least two compartments ( 22 , 24 ), or both wherein the at least two compartments ( 22 , 24 ) border one another and further comprising a flexible membrane ( 40 ) arranged between the at least two compartments ( 22 , 24 ).

7 . The biosensor according to claim 6 , wherein both of the at least two compartments ( 22 , 24 ) each comprise a region ( 30 , 32 ) which is permeable to the at least one analyte and the test medium.

8 . The biosensor according to claim 5 , wherein the pressure sensor ( 56 ) is arranged at least in part in the second compartment ( 24 ) and is surrounded at least in regions by the compensation material ( 70 ).

9 . The biosensor according to claim 8 , wherein the compensation material ( 70 ) is oil ( 72 ).

10 . The biosensor according to claim 1 , wherein the sensor material ( 60 ) is mixed in the pressure measurement chamber ( 20 ) with the compensation material ( 70 ), such that the sensor material ( 60 ) and the compensation material ( 70 ) are arranged in one compartment ( 26 ), and wherein the one compartment ( 26 ) comprises a region ( 30 ) which is permeable to the at least one analyte and a test medium.

11 . The biosensor according to claim 10 , wherein the sensor material ( 60 ) together with the compensation material ( 70 ) form a stack arrangement comprising alternating layers of sensor material ( 60 ) and compensation material ( 70 ), or wherein the sensor material ( 60 ) together with the compensation material ( 70 ) comprise a mixture of particles of sensor material ( 60 ) and compensation material ( 70 ).

12 . The biosensor according to claim 1 , wherein the pressure sensor ( 56 ) is arranged within the pressure measurement chamber ( 20 ) in an additional compartment ( 50 ), wherein the additional compartment ( 50 ) is filled with a pressure transfer medium ( 54 ).

13 . The biosensor according to claim 5 , wherein the first compartment ( 22 ) is coupled to the second compartment ( 24 ) by a pressure piston connection ( 80 ) or by an extendable pipe connection ( 90 ), such that a change in volume of the first compartment ( 22 ) leads to a change in volume of the second compartment ( 24 ).

14 . The biosensor according to claim 1 , wherein the compensation material ( 70 ) is a hydrogel.

15 . The biosensor according to claim 1 , wherein the biosensor ( 10 ) is configured to be implanted in a human or animal body.

16 . The biosensor according to claim 1 , wherein the pressure measurement chamber ( 20 ) comprises a wall, and wherein
the pressure sensor ( 56 ) is connected to the wall of the pressure measurement chamber ( 20 ), or one or more components of the pressure sensor ( 56 ) are part of the wall of the pressure measurement chamber ( 20 ).

Assignees

• Biotronik Se & Co Kg

Inventors

• Ebert Henning
• Bunge Andreas

Classifications

• G01N7/04 Primary

  by absorption or adsorption alone · CPC title

• G01N33/49

  Blood {(chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80)} · CPC title

• A61B2560/0247

  for compensation or correction of the measured physiological value · CPC title

• A61B2562/168

  Fluid filled sensor housings · CPC title

• A61B5/1495

  Calibrating or testing of in-vivo probes · CPC title