Nucleic acid-controlled catalytic rnas for trigger-responsive regulation
US-2024425855-A1 · Dec 26, 2024 · US
Antisense design
US2016348111A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016348111-A1 |
| Application number | US-201615237307-A |
| Country | US |
| Kind code | A1 |
| Filing date | Aug 15, 2016 |
| Priority date | Nov 18, 2002 |
| Publication date | Dec 1, 2016 |
| Grant date | — |
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- Title
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Abstract
Official abstract text for this publication.
A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved antisense properties. The novel oligonucleotides are composed of at least one LNA selected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. The oligonucleotides comprising LNA may also include DNA and/or RNA nucleotides.
First claim
Opening claim text (preview).
1 . A pharmaceutical composition comprising a therapeutically active antisense oligonucleotide construct which (i) comprises at least one locked nucleic acid unit selected from the group consisting of amino-LNA and thio-LNA and derivatives thereof; or (ii) comprises at least two consecutively located locked nucleotide units of which at least one is selected from the group consisting of alpha-L-oxy-LNA and derivatives thereof. 2 .- 42 . (canceled)
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Classifications
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids · CPC title
Heterocyclic radicals containing only nitrogen atoms as ring hetero atom · CPC title
with ribosyl as saccharide radical · CPC title
Position-specific modifications, e.g. on every purine, at the 3'-end · CPC title
modulating the chemical stability, e.g. nuclease-resistance · CPC title
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- What does patent US2016348111A1 cover?
- A novel class of pharmaceuticals which comprises a Locked Nucleic Acid (LNA) which can be used in antisense therapy. These novel oligonucleotides have improved antisense properties. The novel oligonucleotides are composed of at least one LNA selected from beta-D-thio/amino-LNA or alpha-L-oxy/thio/amino-LNA. The oligonucleotides comprising LNA may also include DNA and/or RNA nucleotides.
- Who is the assignee on this patent?
- Roche Innovation Ct Copenhagen As
- What technology area does this patent fall under?
- Primary CPC classification C12N15/113. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Dec 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).