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Post-synthetic chemical modification of rna at the 2'-position of the ribose ring via "click" chemistry
US2016348109A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016348109-A1 |
| Application number | US-201615234736-A |
| Country | US |
| Kind code | A1 |
| Filing date | Aug 11, 2016 |
| Priority date | Jan 22, 2010 |
| Publication date | Dec 1, 2016 |
| Grant date | — |
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- Title
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Abstract
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This invention relates to a 2′-modified RNA agent comprising at least one RNA strand containing a 2′-O substituent having an alkyne functional group attaching to the O atom at the 2′-position on one or more ribose rings, wherein the 2′-O substituent is located at one or more of positions 2, 3, 4, 7, 8, 9, 10, 11, 13, 14, and 16, from 5′-end of the RNA strand. This invention also relates to a 2′-modified RNA agent comprising at least one RNA strand containing a 2′-O substituent having a triazole functional group attaching to the O atom at the 2′-position on one or more ribose rings, wherein the 2′-O substituent is located at one or more of positions 2, 3, 4, 7, 8, 9, 10, 11, 13, 14, and 16, from 5′-end of the RNA strand.
First claim
Opening claim text (preview).
What is claimed is: 1 . A process for introducing 2′-modifications into RNA, said process comprises a) obtaining RNA with an alkyne functional group at the 2′-position on at least one ribose ring; b) creating a solution of RNA in a solvent; and c) adding an organic azide and a metal catalyst to the solution to form a reaction and creating a 2′-modified RNA.
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Classifications
against enzymes (viral enzymes C12N15/1131; receptors C12N15/1138) · CPC title
- C12N15/113Primary
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; {Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing (when used in plants C12N15/8218)} · CPC title
2'-O-R Modification · CPC title
chemically synthesised · CPC title
interfering nucleic acids [NA] · CPC title
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- What does patent US2016348109A1 cover?
- This invention relates to a 2′-modified RNA agent comprising at least one RNA strand containing a 2′-O substituent having an alkyne functional group attaching to the O atom at the 2′-position on one or more ribose rings, wherein the 2′-O substituent is located at one or more of positions 2, 3, 4, 7, 8, 9, 10, 11, 13, 14, and 16, from 5′-end of the RNA strand. This invention also relates to a 2′…
- Who is the assignee on this patent?
- Sirna Therapeutics Inc
- What technology area does this patent fall under?
- Primary CPC classification C12N15/113. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Dec 01 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).