Fused heterocyclic compounds as ion channel modulators

Patent metadata

Field	Value
Publication number	US-2016347744-A1
Application number	US-201615152231-A
Country	US
Kind code	A1
Filing date	May 11, 2016
Priority date	Jul 1, 2011
Publication date	Dec 1, 2016
Grant date	—

Abstract

The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I:

wherein Z 1 , Z 2 , Z 3 , Z 4 , X, Y, R 2 , R 3 and R 4 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.

First claim

What is claimed is:

1 - 66 . (canceled)

67 . A compound represented by the formula:

68 . A pharmaceutical composition comprising a compound represented by the formula

and a pharmaceutically acceptable carrier.

Assignees

• Gilead Sciences Inc

Inventors

• Corkey Britton Kenneth
• Elzein Elfatih
• Graupe Michael
• Guerrero Juan
• Jiang Robert H
• Kalla Rao V
• Koltun Dmitry
• Li Xiaofen
• Martinez Ruben
• Parkhill Eric Q
• Perry Thao
• Venkataramani Chandrasekar
• Zablocki Jeff

Classifications

• A61P5/00

  Drugs for disorders of the endocrine system · CPC title

• A61P9/04

  Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure · CPC title

• A61P9/12

  Antihypertensives · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P9/06

  Antiarrhythmics · CPC title