Method and composition for sterilization of a polymerizable monomer

Patent metadata

Field	Value
Publication number	US-2016346426-A1
Application number	US-201615231885-A
Country	US
Kind code	A1
Filing date	Aug 9, 2016
Priority date	Nov 22, 2011
Publication date	Dec 1, 2016
Grant date	—

Abstract

A methods and mixtures are provided for sterilization of a polymerizable monomer, in which the mixture contains at least the polymerizable monomer, a compound (a), and a compound (b). Compound (a) is selected from the group of compounds (a1), compounds (a2), and compounds (a3), wherein compounds (a1) are represented by general formula (I):

wherein R1, R2, R3, and R4, independent of each other, represent a substituted alkyl residue, a non-substituted alkyl residue, a halogen, a nitro group, or a cyano group; compounds (a2) are selected from the group of dimers of compounds (a1); and compounds (a3) are selected from the group of dialkyldicarbonates. Compound (b) is selected from the group of water and alcohols.

First claim

I/We claim:

1 . A mixture comprising at least one polymerizable monomer, a compound (a), and a compound (b), wherein:
(i) the compound (a) is selected from one of compounds (a1), (a2), and (a3), wherein compound (a1) is a compound represented by formula (I):

wherein R1, R2, R3, and R4 independently represent a hydrogen, a substituted alkyl residue, a non-substituted alkyl residue, a halogen, a nitro group, or a cyano group;
wherein compound (a2) is selected from the group consisting of dimers of compounds (a1); and
wherein compound (a3) is selected from the group consisting of dialkyldicarbonates; and

(ii) the compound (b) is selected from the group consisting of water and alcohols; wherein a fraction of compound (b) in the mixture is no more than 2% by weight relative to a total weight of the mixture.

2 . A mixture comprising at least one polymerizable monomer and a compound (c), wherein compound (c) is selected from the group consisting of alcohols, carboxylic acids having at least three carbon atoms, and esters, wherein compound (c) is a reaction product of a compound (a) and a compound (b), and wherein:
(i) the compound (a) is selected from one of compounds (a1), (a2), and (a3), wherein compound (a1) is a compound represented by formula (I):

wherein R1, R2, R3, and R4 independently represent a hydrogen, a substituted alkyl residue, a non-substituted alkyl residue, a halogen, a nitro group, or a cyano group;
wherein compound (a2) is selected from the group consisting of dimers of compounds (a1); and
wherein compound (a3) is selected from the group consisting of dialkyldicarbonates; and

(ii) the compound (b) is selected from the group consisting of water and alcohols.

3 . The mixture according to claim 1 , wherein the polymerizable monomer is a monomer for radical polymerization.

4 . The mixture according to claim 1 , wherein compound (a) is β-propiolactone.

5 . The mixture according to claim 2 , wherein compound (c) is selected from the group consisting of 3-hydroxypropionic acid and 3-hydroxypropionic acid esters.

6 . The mixture according to claim 1 , wherein the mixture comprises a polymer soluble in the polymerizable monomer.

7 . The mixture according to claim 1 , wherein the mixture comprises a polymer insoluble in the polymerizable monomer.

8 . A kit for producing bone cement, the kit comprising at least a paste A and a paste B, wherein at least one of paste A and paste B comprises a mixture according to claim 2 .

9 . The kit according to claim 8 , wherein paste A and paste B are present in a first package and a second package, respectively.

10 . A bone cement paste comprising a mixture according to claim 2 .

Assignees

• Heraeus Medical Gmbh

Inventors

• Vogt Sebastian

Classifications

• A61L24/046 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds (A61L24/043 takes precedence) · CPC title

• C08F20/56

  Acrylamide; Methacrylamide · CPC title

• A61L2430/02

  for reconstruction of bones; weight-bearing implants · CPC title

• A61L2/16

  using chemical substances · CPC title

• A61L24/06 Primary

  obtained by reactions only involving carbon-to-carbon unsaturated bonds {(A61L24/043, A61L24/046 take precedence)} · CPC title