Treatment of viral infections by modulation of host cell metabolic pathways

Patent metadata

Field	Value
Publication number	US-2016346309-A1
Application number	US-201514977424-A
Country	US
Kind code	A1
Filing date	Dec 21, 2015
Priority date	Jun 1, 2007
Publication date	Dec 1, 2016
Grant date	—

Abstract

Alterations of certain metabolite concentrations and fluxes that occur in response to viral infection are described. Host cell enzymes in the involved metabolic pathways are selected as targets for intervention; i.e., to restore metabolic flux to disadvantage viral replication, or to further derange metabolic flux resulting in “suicide” of viral-infected cells (but not uninfected cells) in order to limit viral propagation. While any of the enzymes in the relevant metabolic pathway can be selected, pivotal enzymes at key control points in these metabolic pathways are preferred as candidate antiviral drug targets. Inhibitors of these enzymes are used to reverse, or redirect, the effects of the viral infection. Drug candidates are tested for antiviral activity using screening assays in vitro and host cells, as well as in animal models. Animal models are then used to test efficacy of candidate compounds in preventing and treating viral infections. The antiviral activity of enzyme inhibitors is demonstrated.

First claim

What is claimed:

1 . A method for treatment or prevention of a virus infection in a human subject, comprising administering an effective amount of 4S-hydroxycitrate, 2,2-difluorocitrate, thiol-citrate, sb201076, sb204990, 2-chloro-1,3,8-trihydroxyl-6-methyl-9-anthrone, purpurone, 3-oxobutylsulfoxyl-CoA, CP610431, CP640186, soraphen-A, sethoxydim, orlistat or CT32228, or a pharmaceutically acceptable salt thereof to a human subject in need thereof.

Assignees

• Univ Princeton

Inventors

• Munger Josh
• Bennett Bryson
• Shenk Thomas
• Rabinowitz Joshua

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/22

  for herpes viruses · CPC title

• A61P31/14

  for RNA viruses · CPC title

• A61P31/12

  Antivirals · CPC title

• A61P31/20

  for DNA viruses · CPC title