Chronic Wound Dressing with Added Anti-Scar Compound

Patent metadata

Field	Value
Publication number	US-2016346133-A1
Application number	US-201615089588-A
Country	US
Kind code	A1
Filing date	Apr 4, 2016
Priority date	Apr 25, 2015
Publication date	Dec 1, 2016
Grant date	—

Abstract

An improved skin substitute is presented comprised of a silicone layer backed up with a woven nylon fabric layer, the silicone layer possessing a regular pattern of slits that permit the porosity of the skin substitute to be adjusted by clinicians by means of applying tension to the skin substitute that differentially opens the slits. A variety of therapeutic substances can be applied to the skin substitute to promote healing, including aloe and other medicinal preparations. A layer of water soluble or water insoluble anti-scar compound is also present, the preferred compound being salinomycin.

First claim

What is claimed is:

1 . A skin substitute, the skin substitute comprised of two layers of material,
the first layer of material, an upper layer, comprised of a silicone membrane, the second layer, a lower layer, comprised of a woven nylon fabric, the silicone membrane selected in a thickness from 0.001″ to 0.005″, the upper layer possessing a plurality of slits in its surface, said slits made after the two layers are joined together, said slits in a regular pattern, the regular pattern comprising alternating perpendicular orientation, both horizontal and vertical, the lower layer woven in a regular pattern with a perpendicular wale and course orientation, the slits on the surface either following the wale direction of the lower layer or crossing the wale direction of the lower layer perpendicularly, said upper layer and said lower layer treated with a plurality of layers of medicinal or therapeutic substances applied to the two layers of the skin substitute, said lower layer also treated with a water soluble or water insoluble anti-scar compound, said slits placed in said upper layer such that the skin substitute has essentially zero porosity with no stretching tension placed on it, the porosity of said skin substitute variable proportional to the amount of stretching tension and the direction in which said stretching tension is placed on the skin substitute, the direction of stretching tension dependent on the orientation of said slits with the wale and course orientation of the woven nylon fabric, the skin substitute designed to place the woven nylon fabric side down on top of a wound when in use, the skin substitute selected to be used in combination with an absorptive dressing placed above said skin substitute over the wound.

2 . The skin substitute of claim 1 where the plurality of layers of medicinal and therapeutic substances are selected from the list of hypoallergenic BSE free USP Pharmaceutical grade gelatin, pure aloe, aloesin, ECM.

3 . The skin substitute of claim 1 where the anti-scar compound is comprised of salinomycin.

4 . The skin substitute of claim 3 , wherein salinomycin is incorporated into (1) the hydrophobic solid silicone component of the skin substitute or (2) the water soluble biological coating used to coat the 3D surface.

Assignees

• Permeaderm Inc A California Corp
• Univ Rochester

Inventors

• Woodroof E Aubrey
• Phipps Richard R

Classifications

• A61F13/00063 Primary

  comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic (drug delivery dressings A61K9/70; chemical aspect of the additives A61L15/00) · CPC title

• A61F13/00042

  Human Necessities · mapped topic

• A61F2013/00238

  characterised by way of knitting or weaving · CPC title

• A61F13/00017

  Human Necessities · mapped topic

• A61F2013/00251

  with macroscopic openings · CPC title