Interleukin 2 receptor gamma gene targeting vector, production of immune cell-deficient transgenic cloned mini pig having vector introduced therein, preparation method therefor and use thereof
US-2016366861-A1 · Dec 22, 2016 · US
Identification of ligands and their use
US2016341727A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016341727-A1 |
| Application number | US-201614994042-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jan 12, 2016 |
| Priority date | Aug 17, 2010 |
| Publication date | Nov 24, 2016 |
| Grant date | — |
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- Title
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Abstract
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A method to identify a peptide and/or its encoding DNA, wherein the peptide binds to a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor, the method comprising: providing a carrier to which is attached a peptide and its encoding DNA; providing an MHC and/or an MHC-like molecule; and exposing the peptide to a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor in the presence of the MHC or MHC-like molecule.
First claim
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1 .- 20 . (canceled) 21 . A carrier to which is attached a peptide, DNA encoding the peptide, and β2 microglobulin. 22 . The carrier of claim 21 to which an MHC or MHC-like molecule is attached. 23 . The carrier of claim 21 wherein the β2 microglobulin is attached to the carrier as part of a larger construct which includes the peptide. 24 . The carrier of claim 21 wherein the peptide and β2 microglobulin are provided connected by a flexible linker. 25 . The carrier of claim 21 wherein the peptide is between about 4 and about 20 amino acids. 26 . The carrier of claim 21 wherein the carrier is a solid support. 27 . The carrier of claim 21 wherein the carrier is a bead. 28 . The carrier of claim 21 wherein the carrier is multivalent. 29 . A carrier to which is attached a peptide, DNA encoding the peptide, and β2 microglobulin and/or an MHC or MHC-like molecule. 30 . The use of a carrier according to claim 21 to identify an epitope recognised by a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor. 31 . A kit for screening for a T-cell epitope and/or an NK-cell epitope and/or an NKT-cell epitope, wherein the kit comprises a carrier to which is attached a peptide, DNA encoding the peptide and β2 microglobulin. 32 . The kit of claim 31 further including instructions to fold the peptide and β2 microglobulin.
Assignees
Inventors
Classifications
the carrier being characterised by its particulate form · CPC title
White blood cells · CPC title
MHC-molecules, e.g. HLA-molecules · CPC title
- G01N33/56977Primary
HLA or MHC typing · CPC title
Protein x Protein interaction, e.g. two hybrid selection · CPC title
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- What does patent US2016341727A1 cover?
- A method to identify a peptide and/or its encoding DNA, wherein the peptide binds to a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell receptor, the method comprising: providing a carrier to which is attached a peptide and its encoding DNA; providing an MHC and/or an MHC-like molecule; and exposing the peptide to a T-cell receptor and/or an NK-cell receptor and/or an NKT-cell rece…
- Who is the assignee on this patent?
- Isis Innovation
- What technology area does this patent fall under?
- Primary CPC classification G01N33/56977. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Thu Nov 24 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).