Article used in contact with living body or biological sample, medical instrument, and artificial joint
US-2020197577-A1 · Jun 25, 2020 · US
US2016339154A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016339154-A1 |
| Application number | US-201515113940-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jan 27, 2015 |
| Priority date | Jan 27, 2014 |
| Publication date | Nov 24, 2016 |
| Grant date | — |
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Described here is a graphene-catalysts conjugate, comprising: a graphene support; a first catalyst conjugated to the graphene support; and a second catalyst conjugated to the graphene support, and the second catalyst is different from the first catalyst. In some embodiments, the first catalyst and the second catalyst correspond to a tandem catalytic system to drive a chemical transformation.
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1 . A graphene-catalysts conjugate, comprising: a graphene support; a first catalyst conjugated to the graphene support; and a second catalyst conjugated to the graphene support, and the second catalyst is different from the first catalyst. 2 . The graphene-catalysts conjugate of claim 1 , wherein the first catalyst and the second catalyst correspond to a tandem catalytic system to drive a chemical transformation. 3 . The graphene-catalysts conjugate of claim 1 , wherein the first catalyst is a molecular catalyst. 4 . The graphene-catalysts conjugate of claim 1 , wherein the first catalyst is an organometallic catalyst. 5 . The graphene-catalysts conjugate of claim 1 , wherein the first catalyst is a metalloporphyrin. 6 . The graphene-catalysts conjugate of claim 1 , wherein the first catalyst is hemin. 7 . The graphene-catalysts conjugate of claim 1 , wherein the first catalyst is conjugated to the graphene support through π-π interactions. 8 . The graphene-catalysts conjugate of claim 1 , wherein the second catalyst is an enzymatic catalyst. 9 . The graphene-catalysts conjugate of claim 1 , wherein the second catalyst is an oxido-reductase. 10 . The graphene-catalysts conjugate of claim 1 , wherein the second catalyst is glucose oxidase. 11 . A biocompatible film, comprising: a polymer film; and a graphene-catalysts conjugate of claim 1 embedded in the polymer film. 12 . A biomedical device, comprising: a main body portion; and a surface coating on the main body portion, and the surface coating includes a graphene-catalysts conjugate of claim 1 embedded in the surface coating. 13 . The biomedical device of claim 12 , which is an implant. 14 . The biomedical device of claim 12 , which is a catheter, a vascular graft, a biosensor, or a heart valve. 15 . A method for making the graphene-catalysts conjugate of claim 1 , comprising covalently linking the second catalyst to a conjugate of the graphene support and the first catalyst. 16 . The method of claim 15 , wherein the first catalyst is hemin which is conjugated to the graphene support through π-π interactions. 17 . The method of claim 16 , wherein the second catalyst is glucose oxidase, and wherein the glucose oxidase is covalently linked to the graphene support through a coupling agent. 18 . A method for making the biocompatible film of claim 11 , comprising coating a surface with a composition comprising the polymer mixed with the graphene-catalysts conjugate. 19 . A method for making the biomedical device of claim 12 , comprising coating the main body portion with a composition comprising the graphene-catalysts conjugate. 20 . A method for improving the antithrombotic property of an implant, comprising coating the implant with a composition comprising the graphene-catalysts conjugate of claim 1 .
containing enzymes · CPC title
Carbon · CPC title
Enzymes or microbial cells immobilised on or in an inorganic carrier · CPC title
characterised by the choice of an antithrombatic agent other than heparin (heparinoïd A61L33/08; polypeptides A61L33/12) · CPC title
Glucose oxidase (1.1.3.4) · CPC title
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